ArticleEBioMedicine2019
The browning of white adipose tissue and body weight loss in primary hyperparathyroidism.
Article in EBioMedicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 44 citations in OpenAlex.
- Parathyroid hormone enhances appetite and fails to reduce adiposity in ob/ob mice.Pflugers Archiv : European journal of physiology · 2026Article
- Heterogeneous Phenotypes of Primary Hyperparathyroidism in Romania: Characterization of a Large Cohort.Journal of clinical medicine · 2026Article
- 10-year cardiovascular disease risk and its contributing factors in primary hyperparathyroidism.Endocrine · 2026Article
- Significance of neuroendocrine systems and the gut-brain axis (GBA) in the regulation of obesity.PeerJ · 2026Review
- The role of bone in whole-body energy metabolism.Nature reviews. Endocrinology · 2025Review
- Characteristics of lipid metabolism and fat distribution in patients with primary hyperparathyroidism and their Mendelian randomization study.Endocrine · 2025Article
- Primary hyperparathyroidism due to ectopic parathyroid adenoma with bone lesions mimicking skeletal neoplasm: a case report.AME case reports · 2025Article
- GRP75 triggers white adipose tissue browning to promote cancer-associated cachexia.Signal transduction and targeted therapy · 2024Article
- Unusual body weight loss due to primary hyperparathyroidism: A case study with literature review.Heliyon · 2024Article
- Uremic sarcopenia: the role of intramuscular adipose tissue as a potential early identifier.Frontiers in medicine · 2024Article
- Association of serum intact parathyroid hormone levels with sarcopenia in patients undergoing peritoneal dialysis.Frontiers in medicine · 2024Article
- Ectopic parathyroid adenoma on sternocleidomastoid muscle: a case report.Frontiers in oncology · 2024Article
- The Mutual Interplay between Bone, Glucose and Lipid Metabolism: The Role of Vitamin D and PTH.Nutrients · 2023Article
- Improvement of nutritional status after parathyroidectomy in patients receiving maintenance hemodialysis.Frontiers in medicine · 2023Article
- Exosomal IL-8 derived from Lung Cancer and Colon Cancer cells induced adipocyte atrophy via NF-κB signaling pathway.Lipids in health and disease · 2022Article
- Brown Adipose Tissue Biodistribution and Correlations Particularities in Parathyroid Pathology Personalized Diagnosis.Diagnostics (Basel, Switzerland) · 2022Article
- Article
- Epidemiology, Pathophysiology, and Genetics of Primary Hyperparathyroidism.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Review
- Metabolic Advantage of 25(OH)DCells · 2022Article
- Severe hyperparathyroidism is associated with nutritional impairment in maintenance hemodialysis patients.Frontiers in nutrition · 2022Article
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Authors and funding
19 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundParathyroid hormone related protein (PTHrP) triggers white adipose tissue (WAT) browning and cachexia in lung cancer mouse models. It remains unknown whether excessive PTH secretion affects WAT browning and to what extent it contributes to body weight change in primary hyperparathyroidism (PHPT).
methodsUsing the adeno-associated virus injection, Pth gene over-expressed mice mimicking PHPT were firstly established to observe their WAT browning and body weight alteration. The association between PTH and body weight was investigated in 496 PHPT patients. The adipose browning activities of 20 PHPT and 60 control subjects were measured with PET/CT scanning.
findingsElevated plasma PTH triggered adipose tissue browning, leading to increased energy expenditure, reduced fat content, and finally decreased body weight in PHPT mice. Higher circulating PTH levels were associated with lower body weight (β = -0.048, P = .0003) independent of renal function, serum calcium, phosphorus,and albumin levels in PHPT patients. PHPT patients exhibited both higher prevalence of detectable brown/beige adipose tissue (20% vs 3.3%, P = .03) and increased browning activities (SUV in cervical adipose was 0.77 vs 0.49,P = .02) compared with control subjects.
interpretationElevated serum PTH drove WAT browning program, which contributed in part to body weight loss in both PHPT mice and patients. These results give insights into the novel pathological effect of PTH and are of importance in understanding the metabolic changes of PHPT. FUND: This research is supported by the National Key Research and Development Program of China and National Natural Science Foundation of China.
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