Evidence map›Paper›PMID 30528449›Full record

Observational studyHeart rhythm2019

Incidence and effect of early postoperative ventricular arrhythmias after congenital heart surgery.

Sarah R Fuchs, Andrew H Smith, Sara L Van Driest, Kim F Crum, Todd L Edwards, Prince J Kannankeril

Open access · greenAbstract readObservational Study
In one paragraph

Observational study in Heart rhythm, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Early Mortality in Cardiac Surgery - Is Lactate Significant?Brazilian journal of cardiovascular surgery · 2024
    Article
  5. Review
  6. Discovery ofBiology · 2023
    Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Sarah R FuchsDepartment of Pediatrics, Thomas P. Graham Jr. Division of Cardiology, Vanderbilt University Medical Center, Nashville, Tennessee. Electronic address: Sarah.Fuchs@vumc.org.
Andrew H SmithDepartment of Pediatrics, Thomas P. Graham Jr. Division of Cardiology, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Pediatrics, Division of Pediatric Critical Care, Vanderbilt University Medical Center, Nashville, Tennessee.
Sara L Van DriestDepartment of Pediatrics, Division of General Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee.
Kim F CrumDepartment of Pediatrics, Thomas P. Graham Jr. Division of Cardiology, Vanderbilt University Medical Center, Nashville, Tennessee.
Todd L EdwardsDepartment of Medicine, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, Tennessee.
Prince J KannankerilDepartment of Pediatrics, Thomas P. Graham Jr. Division of Cardiology, Vanderbilt University Medical Center, Nashville, Tennessee.
Vanderbilt University Medical Center · US

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Developmental Determinants of Cardiovascular DiseaseT32HL105334 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BALDWIN, H SCOTT · 2011 to 2021
$4.3M
Pharmacogenetics and Personalized Medicine after Cardiac Surgery in ChildrenR01HD084461 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI EDWARDS, TODD L, KANNANKERIL, PRINCE JOSEPH · 2016 to 2020
$3.1M
Doris Duke Charitable Foundation 2017075NCATS NIH HHS UL1 TR000445NHLBI NIH HHS T32 HL105334NICHD NIH HHS R01 HD084461
6 · The paper itself

Abstract

backgroundPostoperative arrhythmias after pediatric congenital heart disease (CHD) surgery are a known cause of morbidity and are associated with mortality. A comprehensive evaluation of early postoperative ventricular arrhythmias (VAs) after CHD surgery has not been reported.

objectivesWe sought to determine the incidence of in-hospital VAs after CHD surgery and assess the clinical relevance of this arrhythmia during the postoperative hospital course.

methodsPatients undergoing CHD surgery at our center from September 2007 through December 2016 were prospectively enrolled. Univariate and multivariate analysis was used to assess the association between postoperative VAs and in-hospital mortality, adjusting for postoperative extracorporeal membrane oxygenation and stage 1 single ventricle palliation operations.

resultsA total of 2503 postoperative courses in 1835 patients were included. In all, 464 (18.5%) had VAs, of whom 135 (29.1%) received treatment. Monomorphic ventricular tachycardia was the most frequently treated ventricular arrhythmia (TVA; n=91 [62.3%]). TVAs were associated with increased postoperative extracorporeal membrane oxygenation (13.3% vs 5.5%; P < .001) and in-hospital mortality (14.9% vs 4.0%; P < .001). In multivariate analysis, TVA was an independent risk factor for in-hospital mortality (adjusted odds ratio 2.44; 95% confidence interval 1.21-4.92).

conclusionEarly postoperative VAs after CHD surgery are more common than previously reported. Postoperative VAs are associated with increased in-hospital mortality, and the subgroup of TVAs is an independent risk factor for in-hospital mortality.

Indexed as

Postoperative ComplicationsTachycardia, VentricularVentricular FibrillationCardiac Surgical ProceduresFemaleHeart Defects, CongenitalHospital MortalityHumansIncidenceInfantMalePostoperative PeriodRisk AssessmentRisk FactorsUnited StatesArrhythmiaCardiac surgeryCongenital heart diseasePediatricVentricular tachycardia

Identifiers

PMID30528449
PMCPMC6491269
OpenAlexW2903537967

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.