Evidence map›Paper›PMID 30528424›Full record

ArticleDiagnostic microbiology and infectious disease2019

Molecular characterization of influenza viruses from women and infants in Sarlahi, Nepal.

Jane Kuypers, Helen Y Chu, Charlotte A Gaydos, Joanne Katz, Subarna K Khatry, Steven C LeClerq, James M Tielsch, Mark C Steinhoff, Janet A Englund

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostic microbiology and infectious disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Trial
  2. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Jane KuypersDepartment of Laboratory Medicine, University of Washington, Seattle, WA, USA. Electronic address: kuypers@uw.edu.
Helen Y ChuDepartment of Medicine, University of Washington, Seattle, WA, USA.
Charlotte A GaydosDepartment of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Joanne KatzDepartment of International Health, Johns Hopkins University, Baltimore, MD, USA.
Subarna K KhatryNepal Nutrition Intervention Project, Kathmandu, Nepal.
Steven C LeClerqDepartment of International Health, Johns Hopkins University, Baltimore, MD, USA; Nepal Nutrition Intervention Project, Kathmandu, Nepal.
James M TielschDepartment of Global Health, George Washington University, Washington, DC, USA.
Mark C SteinhoffGlobal Health Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Janet A EnglundSeattle Children's Hospital and Research Foundation, University of Washington, Seattle, WA, USA.
Johns Hopkins University · USUniversity of Washington · USCincinnati Children's Hospital Medical Center · USGeorge Washington University · USNLR Nepal · NPSeattle Children's Hospital · US

Funding

Prospective Community-Based Study of RSV Risk Factors in Nepalese ChildrenK23AI103105 · NIAID · UNIVERSITY OF WASHINGTON · PI CHU, HELEN YING-HUI · 2013 to 2017
$897k
NIAID NIH HHS K23 AI103105NIAID NIH HHS L30 AI107833
6 · The paper itself

Abstract

We used RT-PCR-electrospray ionization-mass spectrometry to identify subtypes and strains of influenza viruses detected during a maternal influenza immunization study in Nepal from May 2011 to April 2014. Hemagglutinin (HA) gene amino acid (aa) sequences of inferred reference strains were compared to those of the vaccines to determine impact of aa relatedness on vaccine efficacy (VE) and disease severity. Three influenza subtypes and many strains were identified. A(H3N2) strains with less than 13 aa differences in HA compared to vaccine strains (matched) showed higher VE than strains with 13 or more differences (mismatched). Yamagata lineage B strains, which were mismatched to the Victoria strain in the vaccine, demonstrated lower VE compared to Victoria strains. Differences in VE were not statistically significant. All A(H1N1pdm) matched the vaccine strain, with 10 or fewer aa differences. Except for women infected with vaccine-matched strains of influenza A, clinical signs and symptoms did not differ between vaccinated and unvaccinated participants.

Indexed as

Amino Acid SequenceFemaleHemagglutinin Glycoproteins, Influenza VirusHumansInfantInfluenza, HumanInfluenza VaccinesNepalOrthomyxoviridaeReverse Transcriptase Polymerase Chain ReactionSequence HomologySpectrometry, Mass, Electrospray IonizationHemagglutinin Glycoproteins, Influenza VirusInfluenza VaccinesElectrospray ionization-mass spectrometryInfluenza immunizationInfluenza subtypes

Identifiers

PMID30528424
PMCPMC7566802
OpenAlexW2900462699

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.