ArticleBiological psychiatry2019
Susceptibility or Resilience to Maltreatment Can Be Explained by Specific Differences in Brain Network Architecture.
Article in Biological psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review and meta-analysis: effects of maternal separation on anxiety-like behavior in rodents.Translational psychiatry · 2020Pooled it
- Promotion of long-term health in early life.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Association of Pain Intensity and Sensitivity with Childhood Trauma in Adolescents with Depressive Disorder: A Multicenter Study.Psychology research and behavior management · 2026Article
- Updated Freudian drive theory: childhood trauma, epigenetics, serotonin and beta endorphin.Frontiers in psychiatry · 2026Article
- Transdiagnostic prevention in youth mental health, Part I: rationale, shared risk factors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- The neurobiological effects of childhood maltreatment on brain structure, function, and attachment.European archives of psychiatry and clinical neuroscience · 2025Review
- The impact of attachment styles and traumatic experiences on maladaptive daydreaming among Iranian population: the mediating role of shame and emotion dysregulation".BMC psychology · 2025Article
- Long-term risk of late-life depression in widowed elderly: a five-year follow-up study.BMC geriatrics · 2025Article
- Neural correlates of reduction in self-judgment after mindful self-compassion training: A pilot study with resting state fMRI.Journal of mood and anxiety disorders · 2025Article
- The Impact of Childhood Maltreatment on Central Pain Processing in Individuals With Psychosis.Bipolar disorders · 2025Article
- Article
- Psychological and neuro-morphological predictors of resilience in healthy adults: the whole is more than the sum of its parts.Frontiers in neuroscience · 2025Review
- Functional brain network organization and multidomain resilience to neighborhood disadvantage in youth.The American psychologist · 2024Article
- The Stress Phenotyping Framework: A multidisciplinary biobehavioral approach for assessing and therapeutically targeting maladaptive stress physiology.Stress (Amsterdam, Netherlands) · 2024Review
- Shared and distinct structural brain networks related to childhood maltreatment and social support: connectome-based predictive modeling.Molecular psychiatry · 2023Article
- The trauma experiences of children with fetal alcohol spectrum disorders: Developmental outcomes utilizing a threat/deprivation child adversity framework.Alcohol, clinical & experimental research · 2023Article
- Child maltreatment and resilience in adulthood: a protocol for a systematic review and meta-analysis.European journal of psychotraumatology · 2023Article
- Impact of childhood maltreatment and resilience on behavioral and neural patterns of inhibitory control during emotional distraction.Development and psychopathology · 2022Article
- Structural brain features signaling trauma, PTSD, or resilience? A systematic exploration.Depression and anxiety · 2022Article
- Sex and sensitive period differences in potential effects of maltreatment on axial versus radial diffusivity in the corpus callosum.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
Corrections and comments
- Commented on by
Authors and funding
6 authors.
Funding
Abstract
backgroundChildhood maltreatment is a major risk factor for psychopathology. However, some maltreated individuals appear remarkably resilient to the psychiatric effects while manifesting the same array of brain abnormalities as maltreated individuals with psychopathology. Hence, a critical aim is to identify compensatory brain alterations that enable resilient individuals to maintain mental well-being despite alterations in stress-susceptible regions.
methodsNetwork models were constructed from diffusion tensor imaging and tractography in physically healthy unmedicated 18- to 25-year-old participants (N = 342, n = 192 maltreated) to develop network-based explanatory models.
resultsFirst, we determined that susceptible and resilient individuals had the same alterations in global fiber stream network architecture using two different definitions of resilience: 1) no lifetime history of Axis I or II disorders, and 2) no clinically significant symptoms of anxiety, depression, anger-hostility, or somatization. Second, we confirmed an a priori hypothesis that right amygdala nodal efficiency was lower in asymptomatic resilient than in susceptible participants or control subjects. Third, we identified eight other nodes with reduced nodal efficiency in resilient individuals and showed that nodal efficiency moderated the relationship between maltreatment and psychopathology. Fourth, we found that models based on global network architecture and nodal efficiency could delineate group membership (control, susceptible, resilient) with 75%, 82%, and 80% cross-validated accuracy.
conclusionsTogether these findings suggest that sparse fiber networks with increased small-worldness following maltreatment render individuals vulnerable to psychopathology if abnormalities occur in specific nodes, but that decreased ability of certain nodes to propagate information throughout the network mitigates the effects and leads to resilience.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.