Evidence map›Paper›PMID 30528291›Full record

ArticleThe ocular surface2019

Hypoxia: A breath of fresh air for the meibomian gland.

Yang Liu, Di Chen, Xiaomin Chen, Wendy R Kam, Mark P Hatton, David A Sullivan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The ocular surface, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 3 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Intense pulsed light for meibomian gland dysfunction: a systematic review and meta-analysis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021
    Pooled it
  3. Pooled it
  4. Trial
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  6. Observational
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Yang LiuSchepens Eye Research Institute, Massachusetts Eye and Ear, and Department of Ophthalmology, Harvard Medical School, Boston, 02114, USA. Electronic address: Yang_Liu@meei.harvard.edu.
Di ChenSchepens Eye Research Institute, Massachusetts Eye and Ear, and Department of Ophthalmology, Harvard Medical School, Boston, 02114, USA; Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China.
Xiaomin ChenSchepens Eye Research Institute, Massachusetts Eye and Ear, and Department of Ophthalmology, Harvard Medical School, Boston, 02114, USA; Zhongnan Hospital, Wuhan University, Wuhan, China.
Wendy R KamSchepens Eye Research Institute, Massachusetts Eye and Ear, and Department of Ophthalmology, Harvard Medical School, Boston, 02114, USA.
Mark P HattonSchepens Eye Research Institute, Massachusetts Eye and Ear, and Department of Ophthalmology, Harvard Medical School, Boston, 02114, USA; Ophthalmic Consultants of Boston, Boston, 02114, USA.
David A SullivanSchepens Eye Research Institute, Massachusetts Eye and Ear, and Department of Ophthalmology, Harvard Medical School, Boston, 02114, USA.
Massachusetts Eye and Ear Infirmary · US

Funding

VISION RESEARCHP30EY003790 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI Patricia Ann D'Amore · 1985 to 2026
$25.5M
Cationic Amphiphilc Drugs for the Treatment of Meibomian Gland DysfunctionR21EY028653 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI SULLIVAN, DAVID A. · 2018 to 2019
$542k
NEI NIH HHS P30 EY003790NEI NIH HHS R21 EY028653
6 · The paper itself

Abstract

purposeOptimal meibomian gland (MG) function is critically important for the health and wellbeing of the ocular surface. We hypothesize that low oxygen (O

methodsWe used human and mouse eyelid segments, and immortalized human MG epithelial cells (IHMGECs) in our studies. To evaluate oxygen (O

resultsOur results demonstrate that human and mouse MGs, but not the surrounding connective tissue, exist in a relatively hypoxic environment in vivo. In addition, our findings show that hypoxia does not influence IHMGEC numbers in basal or proliferating culture conditions, but does stimulate the expression of SREBP-1 in differentiating IHMGECs. Hypoxia also significantly increased DNase II activity, and apparently IHMGEC terminal differentiation.

conclusionsOur Results support our hypotheses, and indicate that relative hypoxia promotes MG function.

Indexed as

AgedAged, 80 and overAnimalsBiomarkersCells, CulturedDisease Models, AnimalEyelidsFemaleGlucose Transporter Type 1HumansHypoxiaMaleMeibomian GlandsMiceMice, Inbred C57BLOxygenBiomarkersGlucose Transporter Type 1OxygenSREBF1 protein, humanSterol Regulatory Element Binding Protein 1DNase IIGlucose transporter 1HypoxiaMeibomian glandPimonidazole

Identifiers

PMID30528291
PMCPMC6529253
OpenAlexW2903224892

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.