ArticleEnvironment international2019
Characterization of age-based trends to identify chemical biomarkers of higher levels in children.
Article in Environment international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Early life phthalate exposure impacts gray matter and white matter volume in infants and young children.Environmental research · 2025Article
- [Simultaneous determination of 10 phthalate metabolites in urine by ultra performance liquid chromatography -tandem mass spectrometry].Se pu = Chinese journal of chromatography · 2025Article
- Young Children's Exposure to Chemicals of Concern in Their Sleeping Environment: An In-Home Study.Environmental science & technology letters · 2025Article
- Are Sleeping Children Exposed to Plasticizers, Flame Retardants, and UV-Filters from Their Mattresses?Environmental science & technology · 2025Article
- Per- and polyfluoroalkyl substances (PFAS) exposure in the U.S. population: NHANES 1999-March 2020.Environmental research · 2025Article
- Widespread occurrence of pesticides in low-income housing.Journal of exposure science & environmental epidemiology · 2024Article
- Environmental chemical-wide associations with immune biomarkers in US adults: A cross-sectional analysis.Environmental research · 2024Article
- High-Throughput Transcriptomics of Nontumorigenic Breast Cells Exposed to Environmentally Relevant Chemicals.Environmental health perspectives · 2024Article
- Characterizing Important Dietary Exposure Sources of Perfluoroalkyl Acids in Inuit Youth and Adults in Nunavik Using a Feature Selection Tool.Environmental health perspectives · 2024Article
- Suspect Screening Analysis of Pooled Human Serum Samples Using GC × GC/TOF-MS.Environmental science & technology · 2024Article
- Characterizing Chemical Exposure Trends from NHANES Urinary Biomonitoring Data.Environmental health perspectives · 2024Article
- Application of anEnvironmental health perspectives · 2021Article
- Transient Multimedia Model for Investigating the Influence of Indoor Human Activities on Exposure to SVOCs.Environmental science & technology · 2020Article
- A comprehensive analysis of racial disparities in chemical biomarker concentrations in United States women, 1999-2014.Environment international · 2020Article
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Authors and funding
5 authors.
Funding
Abstract
backgroundChemical biomarker concentrations are driven by complex interactions between chemical use patterns, exposure pathways, and toxicokinetic parameters such as biological half-lives. Criteria to differentiate legacy from current exposures are helpful for interpreting variation in age-based and time trends of chemical exposure and identifying chemicals to which children are highly exposed. A systematic approach is needed to study temporal trends for a wide range of chemicals in the US population.
objectivesUsing National Health and Nutrition Examination Survey (NHANES) data on measured biomarker concentrations for 141 chemicals from 1999 to 2014, we aim to 1) understand the influence of temporal determinants, in particular time trends, biological half-lives, and restriction dates on age-based trends, 2) systematically define an age-based pattern to identify chemicals with ongoing and high exposure in children, and 3) characterize how age-based trends for six Per- and Polyfluoroalkyl Substances (PFASs) are changing over time.
methodsWe performed an integrated analysis of biological half-lives and restriction dates, compared distributions of chemical biomarker concentrations by age group, and then applied a series of regression models to evaluate the linear (β
resultsFor restricted chemicals, a minimum persistence of 1 year in the human body is needed to observe substantial differences between the less exposed young population and historically exposed adults. We define a metric ( [Formula: see text] ) that identifies several phthalates, brominated flame retardants, pesticides, and metals such as lead and tungsten as elevated and ongoing exposures in children. While a substantial reduction in children's exposures was reflected in PFOS and PFOA, levels of PFNA and PFHxS in children were higher in 2013-2014 compared to those in 1999-2000.
conclusionsIntegrating a series of regression models with systemized stratified analyses by age group enabled us to define an age-based pattern to identify chemicals that are of higher levels in children.
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