Evidence map›Paper›PMID 30528065›Full record

ArticleNeuron2019

Fractionating Blunted Reward Processing Characteristic of Anhedonia by Over-Activating Primate Subgenual Anterior Cingulate Cortex.

Laith Alexander, Philip L R Gaskin, Stephen J Sawiak, Tim D Fryer, Young T Hong, Gemma J Cockcroft, Hannah F Clarke, Angela C Roberts

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 1 pooled it
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 1 synthesis or guideline pooled it, 128 citations in OpenAlex.

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  12. The Orbitofrontal Cortex Underlies Consolidation of Pavlovian Anticipatory Arousal Responses in Macaque Monkeys.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
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  17. Towards an expanded neurocognitive account of ketamine's rapid antidepressant effects.The international journal of neuropsychopharmacology · 2025
    Review
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19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Laith AlexanderDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK; Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, UK.
Philip L R GaskinDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK; Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, UK.
Stephen J SawiakBehavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, UK; Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, UK.
Tim D FryerWolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, UK.
Young T HongWolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, UK.
Gemma J CockcroftDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK; Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, UK.
Hannah F ClarkeDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK; Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, UK.
Angela C RobertsDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK; Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, UK. Electronic address: acr4@cam.ac.uk.
University of Cambridge · GB

Funding

Medical Research Council G1100307Wellcome Trust
6 · The paper itself

Abstract

Anhedonia is a core symptom of depression, but the underlying neurobiological mechanisms are unknown. Correlative neuroimaging studies implicate dysfunction within ventromedial prefrontal cortex, but the causal roles of specific subregions remain unidentified. We addressed these issues by combining intracerebral microinfusions with cardiovascular and behavioral monitoring in marmoset monkeys to show that over-activation of primate subgenual anterior cingulate cortex (sgACC, area 25) blunts appetitive anticipatory, but not consummatory, arousal, whereas manipulations of adjacent perigenual ACC (pgACC, area 32) have no effect. sgACC/25 over-activation also reduces the willingness to work for reward.

Indexed as

RewardAnhedoniaAnimalsBlood PressureCallithrixCitalopramConditioning, ClassicalDiscrimination, PsychologicalDisease Models, AnimalExcitatory Amino Acid AntagonistsFemaleFluorodeoxyglucose F18Food PreferencesGyrus CinguliHumansKetamineCitalopramExcitatory Amino Acid AntagonistsFluorodeoxyglucose F18KetamineProto-Oncogene Proteins c-fosSelective Serotonin Reuptake InhibitorsSucroseanhedoniaanterior cingulatearea 25depressionketaminemarmosetmotivationPET imagingrewardsubgenual

Identifiers

PMID30528065
PMCPMC6344231
OpenAlexW2902821186

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.