Evidence map›Paper›PMID 30527445›Full record

ArticleBiophysical journal2018

Enzymatic Phosphorylation of Ser in a Type I Collagen Peptide.

Yimin Qiu, Erik Poppleton, Arya Mekkat, Hongtao Yu, Sourav Banerjee, Sandra E Wiley, Jack E Dixon, David L Kaplan, Yu-Shan Lin, Barbara Brodsky

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biophysical journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Around the collagen triple helix: an introduction to studying associated genetic and acquired diseases.Matrix biology : journal of the International Society for Matrix Biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Yimin QiuDepartment of Biomedical Engineering, Tufts University, Medford, Massachusetts.
Erik PoppletonDepartment of Biomedical Engineering, Tufts University, Medford, Massachusetts.
Arya MekkatDepartment of Chemistry, Tufts University, Medford, Massachusetts.
Hongtao YuDepartment of Chemistry, Tufts University, Medford, Massachusetts.
Sourav BanerjeeDepartment of Pharmacology, University of California, San Diego, La Jolla, California.
Sandra E WileyDepartment of Pharmacology, University of California, San Diego, La Jolla, California.
Jack E DixonDepartment of Pharmacology, University of California, San Diego, La Jolla, California.
David L KaplanDepartment of Biomedical Engineering, Tufts University, Medford, Massachusetts. Electronic address: david.kaplan@tufts.edu.
Yu-Shan LinDepartment of Chemistry, Tufts University, Medford, Massachusetts.
Barbara BrodskyDepartment of Biomedical Engineering, Tufts University, Medford, Massachusetts. Electronic address: barbara.brodsky@tufts.edu.
Tufts University · USUniversity of California San Diego · US

Funding

REGULATION OF NEUROPEPTIDE BIOSYNTHESISR01DK018849 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DIXON, JACK E, WORBY, CAROLYN ANN · 1986 to 2020
$7.0M
STUDIES ON PANCREATIC HORMONESR37DK018024 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DIXON, JACK E · 1988 to 2013
$5.6M
Stuctural studies of triple-helical proteinsR01GM060048 · NIGMS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI BRODSKY, BARBARA M · 1999 to 2016
$5.1M
STUDIES ON PANCREATIC HORMONESR01DK018024 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DIXON, JACK E, WORBY, CAROLYN ANN · 1986 to 2018
$2.1M
NIDDK NIH HHS R01 DK018024NIDDK NIH HHS R01 DK018849NIDDK NIH HHS R37 DK018024NIGMS NIH HHS R01 GM060048
6 · The paper itself

Abstract

Phosphoproteomics studies have reported phosphorylation at multiple sites within collagen, raising the possibility that these post-translational modifications regulate the physical or biological properties of collagen. In this study, molecular dynamics simulations and experimental studies were carried out on model peptides to establish foundational principles of phosphorylation of Ser residues in collagen. A (Gly-Xaa-Yaa)

Indexed as

Amino Acid SequenceCollagen Type IMitogen-Activated Protein Kinase 3Molecular Dynamics SimulationPeptide FragmentsPhosphorylationProtein Conformation, alpha-HelicalProtein FoldingProtein StabilitySerineCollagen Type IMitogen-Activated Protein Kinase 3Peptide FragmentsSerine

Identifiers

PMID30527445
PMCPMC6302033
OpenAlexW2900884170

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.