Evidence map›Paper›PMID 30527275›Full record

SynthesisThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2019

Aggressive Behaviors in Alzheimer Disease and Mild Cognitive Impairment: Systematic Review and Meta-Analysis.

Rongqin Yu, Anya Topiwala, Robin Jacoby, Seena Fazel

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Physical Violence and Aggression in Parkinson's Disease: A Systematic Review.Journal of the Academy of Consultation-Liaison Psychiatry
    Pooled it
  4. Trial
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  7. Review
  8. Observational
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  12. Review
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  18. Prevalence of dementia and mild cognitive impairment before incarceration.Journal of the American Geriatrics Society · 2022
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rongqin YuDepartment of Psychiatry (RY, AT, RJ, SF), Warneford Hospital, University of Oxford, Oxford, England.
Anya TopiwalaDepartment of Psychiatry (RY, AT, RJ, SF), Warneford Hospital, University of Oxford, Oxford, England.
Robin JacobyDepartment of Psychiatry (RY, AT, RJ, SF), Warneford Hospital, University of Oxford, Oxford, England.
Seena FazelDepartment of Psychiatry (RY, AT, RJ, SF), Warneford Hospital, University of Oxford, Oxford, England. Electronic address: seena.fazel@psych.ox.ac.uk.

Funding

Wellcome Trust 202836/Z/16/Z
6 · The paper itself

Abstract

objectiveWe aim to estimate the risk of perpetrating aggression in Alzheimer disease (AD) and mild cognitive impairment (MCI) by conducting a systematic review and meta-analysis of primary studies.

methodsA systematic search was conducted in six bibliographic databases according to a preregistered protocol. Studies that reported aggressive behaviors in individuals with AD and MCI compared with healthy individuals or those with other dementia etiologies were identified. Risks of aggressive behaviors were assessed using random effects models to calculate pooled odds ratios (ORs). Publication bias was examined.

resultsIn total, 17 studies involving 6,399 individuals with AD and 2,582 with MCI were identified. Compared with healthy individuals, significantly increased risks of aggressive behaviors were found in AD (OR, 4.9, 95% CI, 1.8-13.2) but not in MCI (OR, 1.8, 95% CI, 0.7-4.3). When comparing AD with MCI, the risk in AD was higher (OR, 2.6, 95% CI, 1.7-4.0). We found no differences in risk of aggressive behaviors between AD and other dementia subtypes or between amnestic and nonamnestic MCI.

conclusionIndividuals with AD are at higher risk of manifesting aggressive behaviors than healthy individuals or those with MCI. Our findings not only underscore the necessity of treatment of aggressive behaviors in AD but also highlight the importance of preventing the transition from MCI to AD.

Indexed as

AggressionAlzheimer DiseaseCognitive DysfunctionDisease ProgressionHumansNeuropsychological Testsaggressive behaviorsAlzheimer diseasemild cognitive impairmentsystematic review

Identifiers

PMID30527275
PMCPMC6399100

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.