Evidence map›Paper›PMID 30526860›Full record

ArticleeLife2018

Voltage-dependent dynamics of the BK channel cytosolic gating ring are coupled to the membrane-embedded voltage sensor.

Pablo Miranda, Miguel Holmgren, Teresa Giraldez

Open access · goldAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Fifty years of gating currents and channel gating.The Journal of general physiology · 2023
    Review
  6. Review
  7. Article
  8. Mechanism of voltage sensing in CaProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  9. Article
  10. Review
  11. Coupling of CaProceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Pablo MirandaNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, United States.
Miguel HolmgrenNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, United States.
Teresa GiraldezDepartamento de Ciencias Medicas Basicas, Universidad de La Laguna, San Cristóbal de La Laguna, Spain.ORCID http://orcid.org/0000-0002-4096-810X
National Institutes of Health · USUniversidad de La Laguna · ES

Funding

Structure and Function of Membrane ProteinsZIANS002993 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI HOLMGREN, MIGUEL · 2009 to 2025
$24.0M
European Research Council ERC-CoG-2014-648936Intramural NIH HHS ZIA NS002993NINDS NIH HHS ZIA-NS002993
6 · The paper itself

Abstract

In humans, large conductance voltage- and calcium-dependent potassium (BK) channels are regulated allosterically by transmembrane voltage and intracellular Ca

Indexed as

Allosteric RegulationAnimalsBacterial ProteinsBinding SitesCalciumCell MembraneCytosolFluorescence Resonance Energy TransferGene ExpressionGenes, ReporterGreen Fluorescent ProteinsHumansIon Channel GatingLarge-Conductance Calcium-Activated Potassium ChannelsLuminescent ProteinsMembrane PotentialsBacterial ProteinsCalciumCyan Fluorescent ProteinGreen Fluorescent ProteinsLarge-Conductance Calcium-Activated Potassium ChannelsLuminescent ProteinsPotassiumRecombinant Proteinsyellow fluorescent protein, Bacteriaallosteric modulationBKhumanion channelsmolecular biophysicsstructural biologyxenopus

Identifiers

PMID30526860
PMCPMC6301790
OpenAlexW2903935099

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.