ArticleeLife2018
Highly efficient 5' capping of mitochondrial RNA with NAD
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Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
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Who cites it
56 citing papers in PubMed, 88 citations in OpenAlex.
- A DNA-guided prokaryotic argonaute enables programmable RNA cleavage for sequencing and quality control ofMolecular therapy. Nucleic acids · 2026Article
- Discovery of 5' NAD capped viral RNAs reveals evolutionary divergent 5' metabolite capping across hepaciviruses.Nature communications · 2026Article
- Molecular basis for noncanonical transcription initiation from NpNature chemical biology · 2026Article
- Quantification and transcriptome profiling reveal abundant, dynamic and translatable dephospho-CoA-capped RNAs.Nature biotechnology · 2026Article
- NAD+ capping of sibD transcripts in E. coli is mediated by its minimal promoter and enhanced by ppGpp.Nucleic acids research · 2026Article
- Structural insights into polymerase-catalyzed FAD capping of hepatitis C virus RNA.Nature communications · 2025Article
- Uridine as a hub in cancer metabolism and RNA biology.Experimental & molecular medicine · 2025Review
- The role of NADnpj metabolic health and disease · 2025Review
- Smad4 and TGFβ1 dependent gene expression signatures in conditional intestinal adenoma, organoids and colorectal cancer.Scientific reports · 2025Article
- DragonRNA: Generality of DNA-primed RNA-extension activities by DNA-directed RNA polymerases.Nucleic acids research · 2025Article
- The Mysterious World of Non-Canonical Caps - What We Know and Why We Need New Sequencing Techniques.Chembiochem : a European journal of chemical biology · 2025Review
- Proofreading mechanisms of the innate immune receptor RIG-I: distinguishing self and viral RNA.Biochemical Society transactions · 2024Review
- Crosstalk between vault RNAs and innate immunity.Molecular biology reports · 2024Review
- If the 5' cap fits (wear it) - Non-canonical RNA capping.RNA biology · 2024Review
- Mitochondrial RNA maturation.RNA biology · 2024Review
- Epitranscriptome analysis of NAD-capped RNA by spike-in-based normalization and prediction of chronological age.iScience · 2023Article
- Expression and Purification of Recombinant Human Mitochondrial RNA Polymerase (POLRMT) and the Initiation Factors TFAM and TFB2M.Bio-protocol · 2023Article
- Identification of NAD-RNA species and ADPR-RNA decapping in Archaea.Nature communications · 2023Article
- Selective Characterization of mRNA 5' End-Capping by DNA Probe-Directed Enrichment with Site-Specific Endoribonucleases.ACS pharmacology & translational science · 2023Article
- Future Perspectives for the Identification and Sequencing of Nicotinamide Adenine Dinucleotide-Capped RNAs.Accounts of chemical research · 2023Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Jeremy G Bird *Department of Genetics and Waksman Institute, Rutgers University, United States.
Urmimala Basu *Department of Biochemistry and Molecular Biology, Robert Wood Johnson Medical School, Rutgers University, United States.
David KusterDepartment of Genetics and Waksman Institute, Rutgers University, United States.ORCID http://orcid.org/0000-0002-8157-9223
Aparna RamachandranDepartment of Biochemistry and Molecular Biology, Robert Wood Johnson Medical School, Rutgers University, United States.
Ewa Grudzien-NogalskaDepartment of Cell Biology and Neuroscience, Rutgers University, United States.
Atif TowheedCenter for Mitochondrial and Epigenomic Medicine, The Children's Hospital of Philadelphia, United States.
Douglas C WallaceCenter for Mitochondrial and Epigenomic Medicine, The Children's Hospital of Philadelphia, United States.
Megerditch KiledjianDepartment of Cell Biology and Neuroscience, Rutgers University, United States.
Dmitry TemiakovDepartment of Biochemistry and Molecular Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, United States.
Smita S PatelDepartment of Biochemistry and Molecular Biology, Robert Wood Johnson Medical School, Rutgers University, United States.
Richard H EbrightDepartment of Chemistry and Waksman Institute, Rutgers University, United States.ORCID http://orcid.org/0000-0001-8915-7140
Bryce E NickelsDepartment of Genetics and Waksman Institute, Rutgers University, United States.ORCID http://orcid.org/0000-0001-7449-8831
Rutgers, The State University of New Jersey · USChildren's Hospital of Philadelphia · USThomas Jefferson University · US
Funding
Mechanistic studies of nucleic acid enzymes involved in DNA replication, transcription, and innate immunity.R35GM118086 · NIGMS · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI SMITA S PATEL · 2016 to 2026
$8.9MTranscription: Mechanism and RegulationR35GM118059 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI NICKELS, BRYCE EDWARD · 2016 to 2025
$7.1MThe Intellectual and Developmental Disabilities Research Center at CHOP/PennU54HD086984 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI SCHULTZ, ROBERT THOMAS · 2016 to 2020
$6.3MBACTERIAL TRANSCRIPTION COMPLEXESR37GM041376 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI EBRIGHT, RICHARD H. · 2013 to 2022
$5.0MMolecular Mechanisms of Mitochondrial Transcription and ReplicationR35GM131832 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI Dmitry Temiakov · 2019 to 2026
$4.3MMechanisms of transcription initiation in mitochondriaR01GM104231 · NIGMS · UNIV OF MED/DENT NJ-SCH OSTEOPATHIC MED · PI TEMIAKOV, DMITRY · 2013 to 2017
$1.5MReplication-Transcription switch in mitochondriaR01GM118941 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI TEMIAKOV, DMITRY · 2017 to 2018
$624kNICHD NIH HHS U54 HD086984NIGMS NIH HHS R01 GM104231NIGMS NIH HHS R01 GM118941NIGMS NIH HHS R35 GM118059NIGMS NIH HHS R35 GM118086NIGMS NIH HHS R35 GM131832NIGMS NIH HHS R37 GM041376NIH HHS GM041376NIH HHS GM104231NIH HHS GM118059NIH HHS GM118086NIH HHS GM126488NIH HHS MH108592NIH HHS NS021328NIH HHS OD010944
Abstract
Bacterial and eukaryotic nuclear RNA polymerases (RNAPs) cap RNA with the oxidized and reduced forms of the metabolic effector nicotinamide adenine dinucleotide, NAD
Indexed as
Transcription, GeneticCytoplasmDNA-Directed RNA PolymerasesHumansMitochondriaNADOxidation-ReductionPromoter Regions, GeneticRNA CapsRNA, MitochondrialSaccharomyces cerevisiaeTranscription Initiation SiteDNA-Directed RNA PolymerasesNADRNA CapsRNA, Mitochondrialbiochemistrychemical biologychromosomesE. coligene expressionhumanmetabolismmitochondrianon-canonical initiating nucleotideRNA cappingRNA polymeraseS. cerevisiaetranscription initiation
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.