Evidence map›Paper›PMID 30526853›Full record

ArticleeLife2018

Molecular basis of signaling specificity between GIRK channels and GPCRs.

Kouki K Touhara, Roderick MacKinnon

Open access · goldAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 60 citations in OpenAlex.

  1. Article
  2. Lipid Activation of a Thalamic GPCR Extends Working Memory Time-scales.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. PLCβs are recruited to the plasma membrane in macrophages by both Gβγ and GαProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Review
  6. GluDs are ionotropic dopamine receptors tuned by G-proteins.bioRxiv : the preprint server for biology · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Estimation of Dopamine DACS chemical neuroscience · 2025
    Article
  11. Molecular contacts in self-assembling clusters of membrane proteins.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Review
  13. Higher-order transient membrane protein structures.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  14. Higher-order transient structures and the principle of dynamic connectivity in membrane signaling.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  15. Article
  16. A molecular mechanism to diversify CaNature communications · 2024
    Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kouki K TouharaLaboratory of Molecular Neurobiology and Biophysics, Howard Hughes Medical Institute, The Rockefeller University, New York, United States.ORCID http://orcid.org/0000-0003-3167-9784
Roderick MacKinnonLaboratory of Molecular Neurobiology and Biophysics, Howard Hughes Medical Institute, The Rockefeller University, New York, United States.ORCID http://orcid.org/0000-0001-7605-4679
Howard Hughes Medical Institute · US

Funding

Voltage-Dependent Ion Channel GatingR01GM043949 · NIGMS · ROCKEFELLER UNIVERSITY · PI MACKINNON, RODERICK · 1990 to 2024
$10.1M
Howard Hughes Medical InstituteNIGMS NIH HHS R01 GM043949NIH HHS GM43949
6 · The paper itself

Abstract

Stimulated muscarinic acetylcholine receptors (M2Rs) release Gβγ subunits, which slow heart rate by activating a G protein-gated K

Indexed as

Signal TransductionAnimalsCHO CellsComputer SimulationCricetinaeCricetulusFemaleG Protein-Coupled Inwardly-Rectifying Potassium ChannelsGTP-Binding ProteinsHEK293 CellsHeterotrimeric GTP-Binding ProteinsHumansKineticsMaleMice, Inbred C57BLModels, BiologicalG Protein-Coupled Inwardly-Rectifying Potassium ChannelsGTP-Binding ProteinsHeterotrimeric GTP-Binding ProteinsReceptors, G-Protein-CoupledGIRKGPCRG proteinhumanion channelmolecular biophysicsmousestructural biology

Identifiers

PMID30526853
PMCPMC6335053
OpenAlexW2905372434

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.