Evidence map›Paper›PMID 30526617›Full record

Trial reportJournal of neuroengineering and rehabilitation2018

Stochastic resonance stimulation improves balance in children with cerebral palsy: a case control study.

Anastasia Zarkou, Samuel C K Lee, Laura A Prosser, Sungjae Hwang, John Jeka

Registry-linked trialOpen access · goldAbstract readClinical Trial
In one paragraph

Trial report in Journal of neuroengineering and rehabilitation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02456376 (Sensor Fusion for Balance Control in Children With Cerebral Palsy), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02456376 naunknown statusnot on this map

Sensor Fusion for Balance Control in Children With Cerebral Palsy

TypeinterventionalSponsorTemple UniversityRan2014 to 2016Enrolled20ConditionsCerebral PalsyArmsSensory Integration Testing, SR stimulation & Sensory integration testing
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 1 country.

Anastasia ZarkouSpinal Cord Injury Research Laboratory, Crawford Research Institute, Shepherd Center, 2020 Peachtree Rd NW, Atlanta, GA, 30309, USA. anastasia.zarkou@shepherd.org.ORCID 0000-0001-6331-4291
Samuel C K LeeProgram in Biomechanics and Movement Science & Department of Physical Therapy, University of Delaware, 540 S. College Ave, Newark, DE, 19713, USA.
Laura A ProsserUniversity of Pennsylvania & The Children's Hospital of Philadelphia, 3401 Civic Center Boulevard, Philadelphia, PA, 19104, USA.
Sungjae HwangDepartment of Kinesiology, University of Maryland Eastern Shore, William P. Hytche Center Room 1124, Princess Anne, MD, 21853, USA.
John JekaDepartment of Kinesiology, University of Delaware, 540 S. College Ave, Newark, DE, 19713, USA.
Children's Hospital of Philadelphia · USShepherd Center · USShriners Hospitals for Children - Philadelphia · USUniversity of Delaware · USUniversity of Maryland Eastern Shore · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStochastic Resonance (SR) Stimulation has been used to enhance balance in populations with sensory deficits by improving the detection and transmission of afferent information. Despite the potential promise of SR in improving postural control, its use in individuals with cerebral palsy (CP) is novel. The objective of this study was to investigate the immediate effects of electrical SR stimulation when applied in the ankle muscles and ligaments on postural stability in children with CP and their typically developing (TD) peers.

methodsTen children with spastic diplegia (GMFCS level I- III) and ten age-matched TD children participated in this study. For each participant the SR sensory threshold was determined. Then, five different SR intensity levels (no stimulation, 25, 50, 75, and 90% of sensory threshold) were used to identify the optimal SR intensity for each subject. The optimal SR and no stimulation condition were tested while children stood on top of 2 force plates with their eyes open and closed. To assess balance, the center of pressure velocity (COPV) in anteroposterior (A/P) and medial-lateral (M/L) direction, 95% COP confidence ellipse area (COPA), and A/P and M/L root mean square (RMS) measures were computed and compared.

resultsFor the CP group, SR significantly decreased COPV in A/P direction, and COPA measures compared to the no stimulation condition for the eyes open condition. In the eyes closed condition, SR significantly decreased COPV only in M/L direction. Children with CP demonstrated greater reduction in all the COP measures but the RMS in M/L direction during the eyes open condition compared to their TD peers. The only significant difference between groups in the eyes closed condition was in the COPV in M/L direction.

conclusionsSR electrical stimulation may be an effective stimulation approach for decreasing postural sway and has the potential to be used as a therapeutic tool to improve balance. Applying subject-specific SR stimulation intensities is recommended to maximize balance improvements. Overall, balance rehabilitation interventions in CP might be more effective if sensory facilitation methods, like SR, are utilized by the clinicians.

trial registrationClinicalTrials.gov identifier NCT02456376; 28 May 2015 (Retrospectively registered); https://clinicaltrials.gov/ct2/show/NCT02456376 .

Indexed as

AdolescentCase-Control StudiesCerebral PalsyChildElectric Stimulation TherapyFemaleHumansMalePostural BalanceSensory ThresholdsAfferent stimulationBalanceCerebral palsyPostural controlSomatosensationStochastic resonance stimulation

Identifiers

PMID30526617
PMCPMC6288963
OpenAlexW2903793021

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.