ArticleBMC ophthalmology2018
Contrast sensitivity deficits in patients with mutation-proven inherited retinal degenerations.
Article in BMC ophthalmology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- Contrast Sensitivity and Low-Contrast Visual Acuity in Children With Low Vision.Investigative ophthalmology & visual science · 2026Article
- Comparison of methods for quick estimation of psychometric thresholds.Frontiers in neuroscience · 2026Article
- Assessing Contrast Sensitivity Function in CRB1-Retinopathies: Exploring Child-Friendly Measures of Visual Function.Translational vision science & technology · 2024Article
- Using Hierarchical Bayesian Modeling to Enhance Statistical Inference on Contrast Sensitivity.Translational vision science & technology · 2024Article
- Case report of visual quality in a patient with nephronophthisis 12- associated retinopathy secondary to TTC21B mutation.Documenta ophthalmologica. Advances in ophthalmology · 2024Article
- Predicting contrast sensitivity functions with digital twins.Scientific reports · 2024Article
- Optical Coherence Tomography Split-Spectrum Amplitude-Decorrelation Optoretinography Detects Early Central Cone Photoreceptor Dysfunction in Retinal Dystrophies.Translational vision science & technology · 2024Article
- Update on Clinical Trial Endpoints in Gene Therapy Trials for Inherited Retinal Diseases.Journal of clinical medicine · 2024Review
- Article
- Reduced contrast sensitivity function is correlated with changes to cone photoreceptors in simple high myopia.Frontiers in neuroscience · 2024Article
- Local progression kinetics of macular atrophy in recessive Stargardt disease.Ophthalmic genetics · 2023Article
- A novel quick contrast sensitivity function test in Chinese adults with myopia and its related parameters.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Article
- Correlation between hyperreflective foci and visual function testing in eyes with intermediate age-related macular degeneration.International journal of retina and vitreous · 2023Article
- Systemic epigallocatechin gallate protects against retinal degeneration and hepatic oxidative stress in the P23H-1 rat.Neural regeneration research · 2022Article
- The detrimental effects of progression of retinal degeneration in the visual cortex.Frontiers in cellular neuroscience · 2022Review
- Contrast Sensitivity Loss in Patients With Posttreatment Lyme Disease.Translational vision science & technology · 2021Article
- The Effects of 0.01% Atropine on Adult Myopes' Contrast Sensitivity.Frontiers in neuroscience · 2021Article
- Advancing Clinical Trials for Inherited Retinal Diseases: Recommendations from the Second Monaciano Symposium.Translational vision science & technology · 2020Review
- Patient-reported outcome measures in inherited retinal degeneration gene therapy trials.Ophthalmic genetics · 2020Review
- Monitoring progression of retinitis pigmentosa: current recommendations and recent advances.Expert opinion on orphan drugs · 2020Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPatients with retinal diseases frequently complain of poor visual function even when visual acuity is relatively unaffected. This clinical finding has been attributed to deficits in contrast sensitivity (CS). The purpose of our study was to evaluate the CS in patients with clinical and genetic diagnosis of inherited retinal degeneration (IRD) and relatively preserved visual acuity.
methodsSeventeen patients (30 eyes) with IRD and visual acuity of 20/40 or better, and 18 controls (18 eyes) without any ocular condition underwent slit lamp examination, visual acuity testing via standard Snellen chart testing, CS testing via the Quick Contrast Sensitivity Function (QCSF), and Spectral Domain Optical Coherence Tomography (SD-OCT). CS were measured at 1.0, 1.5, 3.0, 6.0, 12.0, and 18.0 cycles per degree (cpd). T tests with general estimated equations were used to compare CS between groups. Wald chi square followed by pairwise comparisons was used to compare CS between multiple groups.
resultsWe included 12 patients with rod-cone dystrophy (RCD), 3 patients with Stargardt disease (STGD) and 2 patients with Best disease. Patients with IRD had significantly worse CS than controls (p < 0.001) in all spatial frequencies. Patients with STGD had more marked deficits in CS than patients with Best disease (p < 0.001) and RCD (p < 0.001) despite having similar visual acuities.
conclusionPatients with IRD, especially patients with STGD with relatively preserved visual acuity have marked deficits in CS when measured across a range of spatial frequencies. We recommend that clinical trials for STGD incorporate CS measured over a range of spatial frequencies as a secondary clinical endpoint for monitoring visual function. CS may provide an explanation for complaints of visual dysfunction when visual acuity is not significantly altered.
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