ArticleBMC infectious diseases2018
Factors predictive of relapse in adult bacterial osteomyelitis of long bones.
Article in BMC infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 63 citations in OpenAlex.
- Establishment of a human osteocyte model to reveal mechanisms of chronic Staphylococcus epidermidis bone and joint infections.Bone & joint research · 2026Article
- Osteomyelitis.Nature reviews. Disease primers · 2026Review
- Manganese enhances macrophage bactericidal activity in mice with Staphylococcus aureus osteomyelitis via Sirt3-mitophagy axis.Nature communications · 2026Article
- When delay costs a limb: Severe chronic osteomyelitis in a patient with intravenous drug use.Trauma case reports · 2026Article
- Review
- Perceptions, practices, and gaps in osteomyelitis care in rural Rwanda: insights from patients and healthcare workers.BMC health services research · 2026Article
- Early postoperative C-reactive protein-to-albumin ratio for risk stratification of osteomyelitis recurrence after surgical treatment.Frontiers in medicine · 2026Article
- Monitoring intracellular replication dynamics unveils high proportion of non-replicating antibiotic-tolerant Staphylococcus aureus inside osteoblasts.PLoS pathogens · 2025Article
- Investigating the association between polyunsaturated fatty acids and osteomyelitis by Mendelian randomization.Scientific reports · 2025Article
- Observational
- What are the risk factors and microorganism profiles of periprosthetic hip joint infections with a concomitant sinus tract?Archives of orthopaedic and trauma surgery · 2024Article
- The duration of antibiotic therapy for fracture related infection does not affect recurrence but leads to increased adverse effects: a comparison among 6, 12 and 24 weeks of treatment.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024Article
- Distally based sural flaps for soft tissue defects following traumatic osteomyelitis of lower leg and foot.Scientific reports · 2024Article
- Femoral alloprosthesis in bone defect of 30 cm as extremity salvage.Trauma case reports · 2024Article
- Chondrocyte Invasion May Be a Mechanism for Persistent Staphylococcus Aureus Infection In Vitro.Clinical orthopaedics and related research · 2024Article
- Predictors of Developing a Complex Course of Osteomyelitis in Patients with Sickle Cell Anaemia.Sultan Qaboos University medical journal · 2024Article
- Aberrant Expression of SLC7A11 Impairs the Antimicrobial Activities of Macrophages inInternational journal of biological sciences · 2024Article
- A Tale of Two Diagnoses; Gout Vs Chronic Osteomyelitis. A Case Report.Journal of community hospital internal medicine perspectives · 2024Article
- The risk of osteomyelitis after mandibular fracture is doubled in men versus women: analysis of 300,000 patients.Scientific reports · 2023Article
- Surgical management of chronic osteomyelitis: Organisms, recurrence and treatment outcome.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2023Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOsteomyelitis is a difficult-to-cure infection with a high relapse rate despite combined medical and surgical therapies. Some severity factors, duration of antimicrobial therapy and type of surgical procedure might influence osteomyelitis relapse.
methods116 patients with osteomyelitis were followed for ≥1 year after hospital discharge. Demographic, microbiological and clinical data, eight severity factors and treatment (surgical and antibiotic) were analyzed.
resultsMean age was 53 years and 74.1% were men. Tibia (62.1%) and S. aureus (58.5%) were the most commonly involved bone and bacteria, respectively. Mean follow-up was 67.1 months. Forty-six patients underwent bone debridement, 61 debridement plus flap coverage and 9 antimicrobial therapy only. Twenty-six patients (22.4%) relapsed, at a mean of 11.2 months since hospital discharge. Duration > 3 months (p = 0.025), number of severity factors (P = 0.02) and absence of surgery (P = 0.004) were associated with osteomyelitis relapse in the univariate analysis. In the Cox regression analysis, osteomyelitis duration > 3 months (P = 0.012), bone exposure (P = 0.0003) and type of surgery (P < 0.0001) were associated with relapse. Regarding the surgical modalities, bone debridement with muscle flap was associated with better osteomyelitis outcomes, as compared with no surgery (P < 0.0001) and debridement only (P = 0.004).
conclusionsOsteomyelitis extending for > 3 months, bone exposure and treatment other than surgical debridement with muscular flap are risk factors for osteomyelitis relapse.
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