Observational studyBMC ophthalmology2018
Optical coherence tomography angiography of the macula and optic nerve head: microvascular density and test-retest repeatability in normal subjects.
Observational study in BMC ophthalmology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Comparison of the Effects of Latanoprostene Bunod and Timolol on Retinal Blood Vessel Density: A Randomized Clinical Trial.American journal of ophthalmology · 2022Trial
- Longitudinal evaluation of optic nerve head perfusion after phacoemulsification using OCT angiography.International ophthalmology · 2026Article
- Article
- Chronic alcohol consumption on retinal microcirculation in healthy subjects: an optic coherence tomography angiography study.International journal of ophthalmology · 2026Article
- Papillary and peripapillary vascular densities and corresponding correlation with peripapillary retinal thicknesses using optical coherence tomography angiography in healthy children and adolescents.Scientific reports · 2024Article
- Evaluation of the long-term variability of macular OCT/OCTA and visual field parameters.The British journal of ophthalmology · 2024Observational
- The characteristics of dome-shaped macula in Chinese children aged 4-6 years using optical coherence tomography angiography.BMC ophthalmology · 2023Article
- Optical coherence tomography angiography in healthy children: normative data and age-related changes in microvascular structure of the optic disk and macula.International ophthalmology · 2022Article
- Assessment of the retinal vasculature in healthy Chinese preschool children aged 4-6 years old using optical coherence tomography angiography.BMC ophthalmology · 2021Article
- Comparison of two different optical coherence tomography angiography devices in detecting healthy versus glaucomatous eyes - an observational cross-sectional study.BMC ophthalmology · 2020Observational
- Evaluation of microvascular changes in optic disc and retina by optical coherence tomography angiography during Valsalva maneuver.International ophthalmology · 2020Article
- Evaluation of the different thresholding strategies for quantifying choriocapillaris using optical coherence tomography angiography.Quantitative imaging in medicine and surgery · 2020Article
- Effect of silicone oil on peripapillary capillary density in patients with rhegmatogenous retinal detachment.BMC ophthalmology · 2020Article
- Transient effect of suction on the retinal neurovasculature in myopic patients after small-incision lenticule extraction.Journal of cataract and refractive surgery · 2020Article
- Integrating photoacoustic microscopy, optical coherence tomography, OCT angiography, and fluorescence microscopy for multimodal imaging.Experimental biology and medicine (Maywood, N.J.) · 2020Article
- The vascular densities of the macula and optic disc in normal eyes from children by optical coherence tomography angiography.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020Article
- Automatic Visual Acuity Estimation by Means of Computational Vascularity Biomarkers Using Oct Angiographies.Sensors (Basel, Switzerland) · 2019Article
- Assessment of retinal nerve fiber thickness and optic nerve head blood flow in female patients diagnosed with fibromyalgia syndrome.Arquivos brasileiros de oftalmologiaArticle
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite the potential usefulness of optical coherence tomography angiography in retinal and optic disc conditions, the reliability of the imaging modality remains unclear. This study set out to measure the microvascular density of macula and optic disc by mean of optical coherence tomography angiography and report the repeatability of the vessel density measurements.
methodsCross sectional observational cohort study. Subjects with normal eyes were recruited. Two sets of optical coherence tomography angiography images of macula and optic nerve head were acquired during one visit. Novel in-house developed software was used to count the pixels in each images and to compute the microvessel density of the macula and optic disc. Data were analysed to determine the measurement repeatability.
resultsA total of 176 eyes from 88 consecutive normal subjects were recruited. For macular images, the mean vessel density at superficial retina, deep retina, outer retina and choriocapillaries segment was OD 0.113 and OS 0.111, OD 0.239 and OS 0.230, OD 0.179 and OS 0.164, OD 0.237 and OS 0.215 respectively. For optic disc images, mean vessel density at vitreoretinal interface, radial peripapillary capillary, superficial nerve head and disc segment at the level of choroid were OD 0.084 and OS 0.085, OD 0.140 and OS 0.138, OD 0.216 and OS 0.209, OD 0.227 and OS 0.236 respectively. The measurement repeatability tests showed that the coefficient of variation of macular scans, for right and left eyes, ranged from 6.4 to 31.1% and 5.3 to 59.4%. Likewise, the coefficient of variation of optic disc scans, for right and left eyes, ranged from 14.3 to 77.4% and 13.5 to 75.3%.
conclusionsOptical coherence tomography angiography is a useful modality to visualise the microvasculature plexus of macula and optic nerve head. The vessel density measurement of macular scan by mean of optical coherence tomography angiography demonstrated good repeatability. The optic disc scan, on the other hand, showed a higher coefficient of variation indicating a lower measurement repeatability than macular scan. Interpretation of optical coherence tomography angiography should take into account test-retest repeatability of the imaging system.
trial registrationNational Healthcare Group Domain Specific Review Board ( NHG DSRB ) Singapore. DSRB Reference: 2015/00301.
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