Evidence map›Paper›PMID 30526502›Full record

ArticleBMC cardiovascular disorders2018

Prognostic value of rising mean platelet volume during hospitalization in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention.

Eyup Avci, Tuncay Kiris, Aykan Çelik, Eser Variş, Fatma Kayaalti Esin, Diyar Köprülü, Hasan Kadi

Open access · goldAbstract read
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In one paragraph

Article in BMC cardiovascular disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Eyup AvciDepartment of Cardiology, Medical School, Balikesir University, Balikesir, Turkey.ORCID 0000-0002-7790-8450
Tuncay KirisDepartment of Cardiology, Ataturk Training and Research Hospital, Izmir Katip Celebi University, Basın Sitesi, 35360, Izmir, Turkey. drtkiris@hotmail.com.
Aykan ÇelikDepartment of Cardiology, Ataturk Training and Research Hospital, Izmir Katip Celebi University, Basın Sitesi, 35360, Izmir, Turkey.
Eser VarişDepartment of Cardiology, Dr. Burhan Nalbantoğlu State Hospital, Nicosia, Cyprus.
Fatma Kayaalti EsinDepartment of Cardiology, Ataturk Training and Research Hospital, Izmir Katip Celebi University, Basın Sitesi, 35360, Izmir, Turkey.
Diyar KöprülüDepartment of Cardiology, Ordu State Hospital, Ordu, Turkey.
Hasan KadiDepartment of Cardiology, Medical School, Balikesir University, Balikesir, Turkey.
Izmir Kâtip Çelebi University · TRBalıkesir University · TRNicosia General Hospital · CYOrdu University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe prognostic significance of changes in mean platelet volume (MPV) during hospitalization in ST segment elevation myocardial infarction (STEMI) patients underwent primary percutaneous coronary intervention (pPCI) has not been previously evaluated. The aim of this study was to determine the association of in-hospital changes in MPV and mortality in these patients.

methodsFour hundred eighty consecutive STEMI patients were enrolled in this retrospective study. The patients were grouped as survivors (n = 370) or non-survivors (n = 110). MPV at admission, and at 48-72 h was evaluated. Change in MPV (MPV at 48-72 h minus MPV on admission) was defined as ΔMPV.

resultsAt follow-up, long-term mortality was 23%. The non-survivors had a high ΔMPV than survivors (0.37 (- 0.1-0.89) vs 0.79 (0.30-1.40) fL, p <  0.001). A high ΔMPV was an independent predictor of all cause mortality ((HR: 1.301 [1.070-1.582], p = 0.008). Morever, for long-term mortality, the AUC of a multivariable model that included age, LVEF, Killip class, and history of stroke/TIA was 0.781 (95% CI:0.731-0.832, p <  0.001). When ΔMPV was added to a multivariable model, the AUC was 0.800 (95% CI: 0.750-0.848, z = 2.256, difference p = 0.0241, Fig. 1). Also, the addition of ΔMPV to a multivariable model was associated with a significant net reclassification improvement estimated at 24.5% (p = 0.027) and an integrated discrimination improvement of 0.014 (p = 0.0198).

conclusionsRising MPV during hospitalization in STEMI patients treated with pPCI was associated with long-term mortality.

Indexed as

Blood PlateletsHospitalizationMean Platelet VolumePercutaneous Coronary InterventionAgedAged, 80 and overFemaleHospital MortalityHumansMaleMiddle AgedPredictive Value of TestsRetrospective StudiesRisk FactorsST Elevation Myocardial InfarctionTime FactorsMean platelet volumeMortalityST segment elevation myocardial infarction

Identifiers

PMID30526502
PMCPMC6286559
OpenAlexW2904890744

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.