Evidence map›Paper›PMID 30526359›Full record

ArticleRadiology2019

Combined Benefit of Quantitative Three-Compartment Breast Image Analysis and Mammography Radiomics in the Classification of Breast Masses in a Clinical Data Set.

Karen Drukker, Maryellen L Giger, Bonnie N Joe, Karla Kerlikowske, Heather Greenwood, Jennifer S Drukteinis, Bethany Niell, Bo Fan, Serghei Malkov, Jesus Avila and 2 more

Abstract read
In one paragraph

Article in Radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  12. Deep learning model improves radiologists' performance in detection and classification of breast lesions.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2021
    Article
  13. Review
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  17. Microscopic Tumour Classification by Digital Mammography.Journal of healthcare engineering · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Karen DrukkerFrom the Department of Radiology, University of Chicago, 5481 S Maryland Ave, MC2026, Chicago, IL 60637 (K.D., M.L.G.); Department of Radiology and Biomedical Imaging (B.N.J., H.G., B.F., S.M., J.A., L.K., J.S.) and Department of Medicine and Epidemiology (K.K.), University of California, San Francisco, San Francisco, Calif; and Department of Diagnostic Radiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Fla (J.S.D., B.N.).ORCID 0000-0001-6544-3476
Maryellen L GigerFrom the Department of Radiology, University of Chicago, 5481 S Maryland Ave, MC2026, Chicago, IL 60637 (K.D., M.L.G.); Department of Radiology and Biomedical Imaging (B.N.J., H.G., B.F., S.M., J.A., L.K., J.S.) and Department of Medicine and Epidemiology (K.K.), University of California, San Francisco, San Francisco, Calif; and Department of Diagnostic Radiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Fla (J.S.D., B.N.).
Bonnie N JoeFrom the Department of Radiology, University of Chicago, 5481 S Maryland Ave, MC2026, Chicago, IL 60637 (K.D., M.L.G.); Department of Radiology and Biomedical Imaging (B.N.J., H.G., B.F., S.M., J.A., L.K., J.S.) and Department of Medicine and Epidemiology (K.K.), University of California, San Francisco, San Francisco, Calif; and Department of Diagnostic Radiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Fla (J.S.D., B.N.).ORCID 0000-0001-9333-1463
Karla KerlikowskeFrom the Department of Radiology, University of Chicago, 5481 S Maryland Ave, MC2026, Chicago, IL 60637 (K.D., M.L.G.); Department of Radiology and Biomedical Imaging (B.N.J., H.G., B.F., S.M., J.A., L.K., J.S.) and Department of Medicine and Epidemiology (K.K.), University of California, San Francisco, San Francisco, Calif; and Department of Diagnostic Radiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Fla (J.S.D., B.N.).
Heather GreenwoodFrom the Department of Radiology, University of Chicago, 5481 S Maryland Ave, MC2026, Chicago, IL 60637 (K.D., M.L.G.); Department of Radiology and Biomedical Imaging (B.N.J., H.G., B.F., S.M., J.A., L.K., J.S.) and Department of Medicine and Epidemiology (K.K.), University of California, San Francisco, San Francisco, Calif; and Department of Diagnostic Radiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Fla (J.S.D., B.N.).
Jennifer S DrukteinisFrom the Department of Radiology, University of Chicago, 5481 S Maryland Ave, MC2026, Chicago, IL 60637 (K.D., M.L.G.); Department of Radiology and Biomedical Imaging (B.N.J., H.G., B.F., S.M., J.A., L.K., J.S.) and Department of Medicine and Epidemiology (K.K.), University of California, San Francisco, San Francisco, Calif; and Department of Diagnostic Radiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Fla (J.S.D., B.N.).
Bethany NiellFrom the Department of Radiology, University of Chicago, 5481 S Maryland Ave, MC2026, Chicago, IL 60637 (K.D., M.L.G.); Department of Radiology and Biomedical Imaging (B.N.J., H.G., B.F., S.M., J.A., L.K., J.S.) and Department of Medicine and Epidemiology (K.K.), University of California, San Francisco, San Francisco, Calif; and Department of Diagnostic Radiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Fla (J.S.D., B.N.).
Bo FanFrom the Department of Radiology, University of Chicago, 5481 S Maryland Ave, MC2026, Chicago, IL 60637 (K.D., M.L.G.); Department of Radiology and Biomedical Imaging (B.N.J., H.G., B.F., S.M., J.A., L.K., J.S.) and Department of Medicine and Epidemiology (K.K.), University of California, San Francisco, San Francisco, Calif; and Department of Diagnostic Radiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Fla (J.S.D., B.N.).
Serghei MalkovFrom the Department of Radiology, University of Chicago, 5481 S Maryland Ave, MC2026, Chicago, IL 60637 (K.D., M.L.G.); Department of Radiology and Biomedical Imaging (B.N.J., H.G., B.F., S.M., J.A., L.K., J.S.) and Department of Medicine and Epidemiology (K.K.), University of California, San Francisco, San Francisco, Calif; and Department of Diagnostic Radiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Fla (J.S.D., B.N.).
Jesus AvilaFrom the Department of Radiology, University of Chicago, 5481 S Maryland Ave, MC2026, Chicago, IL 60637 (K.D., M.L.G.); Department of Radiology and Biomedical Imaging (B.N.J., H.G., B.F., S.M., J.A., L.K., J.S.) and Department of Medicine and Epidemiology (K.K.), University of California, San Francisco, San Francisco, Calif; and Department of Diagnostic Radiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Fla (J.S.D., B.N.).
Leila KazemiFrom the Department of Radiology, University of Chicago, 5481 S Maryland Ave, MC2026, Chicago, IL 60637 (K.D., M.L.G.); Department of Radiology and Biomedical Imaging (B.N.J., H.G., B.F., S.M., J.A., L.K., J.S.) and Department of Medicine and Epidemiology (K.K.), University of California, San Francisco, San Francisco, Calif; and Department of Diagnostic Radiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Fla (J.S.D., B.N.).
John ShepherdFrom the Department of Radiology, University of Chicago, 5481 S Maryland Ave, MC2026, Chicago, IL 60637 (K.D., M.L.G.); Department of Radiology and Biomedical Imaging (B.N.J., H.G., B.F., S.M., J.A., L.K., J.S.) and Department of Medicine and Epidemiology (K.K.), University of California, San Francisco, San Francisco, Calif; and Department of Diagnostic Radiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Fla (J.S.D., B.N.).

Funding

Lesion Composition and Quantitative Imaging Analysis on Breast Cancer DiagnosisR01CA166945 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI GIGER, MARYELLEN L., SHEPHERD, JOHN ALAN · 2013 to 2017
$3.3M
Quantitative Image Analysis for Assessing Response to Breast Cancer TherapyU01CA195564 · NCI · UNIVERSITY OF CHICAGO · PI GIGER, MARYELLEN L. · 2015 to 2019
$2.5M
NCI NIH HHS R01 CA166945NCI NIH HHS U01 CA195564
6 · The paper itself

Abstract

Purpose To investigate the combination of mammography radiomics and quantitative three-compartment breast (3CB) image analysis of dual-energy mammography to limit unnecessary benign breast biopsies. Materials and Methods For this prospective study, dual-energy craniocaudal and mediolateral oblique mammograms were obtained immediately before biopsy in 109 women (mean age, 51 years; range, 31-85 years) with Breast Imaging Reporting and Data System category 4 or 5 breast masses (35 invasive cancers, 74 benign) from 2013 through 2017. The three quantitative compartments of water, lipid, and protein thickness at each pixel were calculated from the attenuation at high and low energy by using a within-image phantom. Masses were automatically segmented and features were extracted from the low-energy mammograms and the quantitative compartment images. Tenfold cross-validations using a linear discriminant classifier with predefined feature signatures helped differentiate between malignant and benign masses by means of (a) water-lipid-protein composition images alone, (b) mammography radiomics alone, and (c) a combined image analysis of both. Positive predictive value of biopsy performed (PPV

Indexed as

AdultAgedAged, 80 and overBiopsyBreast DiseasesDiagnosis, DifferentialFemaleHumansMammographyMiddle AgedPredictive Value of TestsProspective StudiesRadiographic Image Interpretation, Computer-AssistedSensitivity and Specificity

Identifiers

PMID30526359
PMCPMC6394732

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.