Evidence map›Paper›PMID 30526278›Full record

ReviewRNA biology2019

The nuclear export of circular RNAs is primarily defined by their length.

Zhengguo Li, Michael G Kearse, Chuan Huang

Abstract readReview
In one paragraph

Review in RNA biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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  4. Review
  5. METTL3-dependent mJournal of translational medicine · 2026
    Article
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  7. Article
  8. Review
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  14. Article
  15. Article
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  17. Review
  18. Article
  19. Review
  20. Circular RNAs in cardiovascular diseases.Pharmacology & therapeutics · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Zhengguo Lia School of Life Sciences , Chongqing University , Chongqing , China.
Michael G Kearsec Department of Biochemistry and Biophysics , University of Pennsylvania, Perelman School of Medicine , Philadelphia , PA , USA.ORCID 0000-0002-7025-8803
Chuan Huanga School of Life Sciences , Chongqing University , Chongqing , China.ORCID 0000-0003-2565-9154

Funding

Specialized regulation of non-AUG translationK99GM126064 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI KEARSE, MICHAEL G · 2017 to 2018
$158k
NIGMS NIH HHS K99 GM126064NIH HHS K99GM126064
6 · The paper itself

Abstract

Although it was long assumed that eukaryotic pre-mRNAs are almost always spliced to generate linear mRNAs, it is now clear that thousands of protein-coding genes can be non-canonically spliced using backsplicing to produce circular RNAs (circRNAs). Most mature circRNAs accumulate in the cytoplasm; however, little is known about how circRNAs are exported from the nucleus to the cytoplasm as they lack many of the common signals used for mRNA export. In this point-of-view article, we will discuss our recently identified circRNA nuclear export pathway and address important open questions in the field.

Indexed as

Active Transport, Cell NucleusRNA TransportAmino Acid MotifsAnimalsHumansProtein Interaction Domains and MotifsRNARNA-Binding ProteinsRNA, CircularRNA PrecursorsRNA SplicingRNA StabilityTranscription, GeneticRNARNA-Binding ProteinsRNA, CircularRNA PrecursorsbiogenesiscircRNAfunctionHel25Enuclear exportUAP56URH49

Identifiers

PMID30526278
PMCPMC6380329

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.