ArticleJournal of the American Heart Association2018
Associations of Echocardiography Markers and Vascular Brain Lesions: The ARIC Study.
Article in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Clinical and Imaging Markers of Cardiac Function and Brain Health: A Meta-Analysis of Community-Based Studies.Neurology · 2025Pooled it
- Left Ventricular Hypertrophy and Cerebral Small Vessel Disease: A Systematic Review and Meta-Analysis.Journal of stroke · 2020Pooled it
- Association of Left Ventricular Function With Cerebral Small Vessel Disease and Cognition.Journal of the American Heart Association · 2026Article
- Heart-Brain Axis: Subclinical Cardiovascular Changes and Brain Health.Journal of the American Heart Association · 2026Review
- Association of total cerebral small vessel disease burden with left ventricular hypertrophy and geometry in patients with ischemic stroke.Frontiers in neuroscience · 2026Article
- Clinical research and trials in echocardiography: rationale, requirements and future opportunities.Echo research and practice · 2025Review
- Association between echocardiographic parameters of cardiac structure and function and mild cognitive impairment.BMC cardiovascular disorders · 2025Article
- Association of left atrial function with vascular brain injury: The Atherosclerosis Risk in Communities study.European journal of neurology · 2025Article
- Systemic determinants of brain health in ageing.Nature reviews. Neurology · 2024Review
- Heart failure with preserved ejection fraction.Nature reviews. Disease primers · 2024Review
- Left ventricular hypertrophy as a risk factor for accelerated brain aging: Results from the Study of Health in Pomerania.Human brain mapping · 2024Article
- Echocardiographic correlates of MRI imaging markers of cerebral small-vessel disease in patients with atrial-fibrillation-related ischemic stroke.Frontiers in neurology · 2023Article
- Cardiac Hypertrophy Is Associated With Advanced Brain Aging in the General Population.Journal of the American Heart Association · 2021Article
- Impact of Cardiovascular Hemodynamics on Cognitive Aging.Arteriosclerosis, thrombosis, and vascular biology · 2021Review
- Cardiac Structure and Function Is Associated With Hemispatial Neglect Severity.Frontiers in neurology · 2021Article
- Associations of Echocardiography Markers and Vascular Brain Lesions: The ARIC Study.Journal of the American Heart Association · 2018Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Background Associations between subtle changes in cardiac and cerebral structure and function are not well understood, with some studies suggesting that subclinical cardiac changes may be associated with markers of vascular brain insult. Methods and Results Data from the ARIC (Atherosclerosis Risk in Communities) Study (5th ARIC visit; 2011-2013; N=1974) were used to explore relationships between abnormalities of cardiac structure/function and subclinical brain disease and to test specific associations between those cardiac and vascular brain changes that share a common mechanism. In adjusted models white matter hyperintensities were 0.66 cm
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Registered trials
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