Evidence map›Paper›PMID 30526224›Full record

ReviewInternational journal of radiation biology2019

Therapeutic potential of natural plant products and their metabolites in preventing radiation enteropathy resulting from abdominal or pelvic irradiation.

Rupak Pathak, Sumit K Shah, Martin Hauer-Jensen

Open access · greenAbstract readReview
In one paragraph

Review in International journal of radiation biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Management of gastrointestinal perforation related to radiation.International journal of clinical oncology · 2020
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Rupak Pathaka Division of Radiation Health Department of Pharmaceutical Sciences College of Pharmacy , University of Arkansas for Medical Sciences , Little Rock , AR , USA.
Sumit K Shahb College of Medicine Department of Pathology , University of Arkansas for Medical Sciences , Little Rock , AR , USA.
Martin Hauer-Jensena Division of Radiation Health Department of Pharmaceutical Sciences College of Pharmacy , University of Arkansas for Medical Sciences , Little Rock , AR , USA.
University of Arkansas for Medical Sciences · US

Funding

The Role o f Tetrahydrobiopterin (BH4) Bioavailability in Radiation-induced Skin InjuryP20GM109005 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI BOERMA, MARJAN · 2015 to 2024
$21.1M
NIGMS NIH HHS P20 GM109005
6 · The paper itself

Abstract

Radiation-induced gastrointestinal injury or radiation enteropathy is an imminent risk during radiation therapy of abdominal or pelvic tumors. Despite remarkable technological advancements in image-guided radiation delivery techniques, the risk of intestinal injury after radiotherapy for abdominal or pelvic cancers has not been completely eliminated. The irradiated intestine undergoes varying degrees of adverse structural and functional changes, which can result in transient or long-term complications. The risk of development of enteropathy depends on dose, fractionation, and quality of radiation. Moreover, the patients' medical condition, age, inter-individual sensitivity to radiation and size of the treatment area are also risk factors of radiation enteropathy. Therefore, strategies are needed to prevent radiotherapy-induced undesirable alteration in the gastrointestinal tract. Many natural plant products, by virtue of their plethora of biological activities, alleviate the adverse effects of radiation-induced injury. The current review discusses potential roles and possible mechanisms of natural plant products in suppressing radiation enteropathy. Natural plant products have the potential to suppress intestinal radiation toxicity.

Indexed as

Abdominal NeoplasmsAscorbic AcidBiological ProductsCurcuminGarlicHumansIntestinal DiseasesPelvic NeoplasmsPlant ExtractsRadiation InjuriesVitamin EAscorbic AcidBiological ProductsCurcuminPlant ExtractsVitamin Egastrointestinal tractintestinal radiation toxicityRadiation-induced tissue toxicityradiation protectiontotal body irradiation (TBI)

Identifiers

PMID30526224
PMCPMC6461490
OpenAlexW2904709899

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.