ArticleCirculation. Genomic and precision medicine2018
Bivariate Genome-Wide Association Scan Identifies 6 Novel Loci Associated With Lipid Levels and Coronary Artery Disease.
Article in Circulation. Genomic and precision medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Meta-analysis of sub-Saharan African studies provides insights into genetic architecture of lipid traits.Nature communications · 2022Pooled it
- Evaluating the cardiovascular safety of sclerostin inhibition using evidence from meta-analysis of clinical trials and human genetics.Science translational medicine · 2020Pooled it
- A multi-trait genome-wide association study of coronary artery disease and subclinical atherosclerosis traits.Research square · 2025Article
- The Role of Endothelial Cells in Atherosclerosis: Insights from Genetic Association Studies.The American journal of pathology · 2024Review
- Article
- Genetic Factors for Coronary Heart Disease and Their Mechanisms: A Meta-Analysis and Comprehensive Review of Common Variants from Genome-Wide Association Studies.Diagnostics (Basel, Switzerland) · 2022Review
- Accounting for age of onset and family history improves power in genome-wide association studies.American journal of human genetics · 2022Article
- Article
- Multi-Trait Genome-Wide Association Study of Atherosclerosis Detects Novel Pleiotropic Loci.Frontiers in genetics · 2021Article
- Genome-Wide Identification of Rare and Common Variants Driving Triglyceride Levels in a Nevada Population.Frontiers in genetics · 2021Article
- Weighted Co-Expression Network Analysis Identifies RNF181 as a Causal Gene of Coronary Artery Disease.Frontiers in genetics · 2021Article
- Effect of non-normality and low count variants on cross-phenotype association tests in GWAS.European journal of human genetics : EJHG · 2020Article
- Detecting potential pleiotropy across cardiovascular and neurological diseases using univariate, bivariate, and multivariate methods on 43,870 individuals from the eMERGE network.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2019Article
- Candidate Regulators of Dyslipidemia in Chromosome 1 Substitution Lines Using Liver Co-Expression Profiling Analysis.Frontiers in genetics · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
backgroundPlasma lipid levels are heritable and genetically associated with risk of coronary artery disease (CAD). However, genome-wide association studies (GWAS) routinely analyze these traits independent of one another. Joint GWAS for two related phenotypes can lead to a higher powered analysis to detect variants contributing to both traits.
methodsWe performed a bivariate GWAS to discover novel loci associated with both heart disease, using a CAD meta-analysis (122 733 cases and 424 528 controls), and lipid traits, using results from the Global Lipid Genetics Consortium (188 577 subjects).
resultsWe identified six previously unreported loci at genome-wide significance ( P<5×10
conclusionsWe discovered six novel variants individually associated with both lipids and CAD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.