Evidence map›Paper›PMID 30525786›Full record

ReviewThe American psychologist2018

Marriage, divorce, and the immune system.

Janice K Kiecolt-Glaser

Abstract readReview
In one paragraph

Review in The American psychologist, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Significant other reported outcome measures within European cohorts of severely injured patients: A systematic review.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026
    Pooled it
  2. Trial
  3. How spousal, friend, and family ties predict health: Within- and between-person effects across 16 years.Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43) · 2026
    Article
  4. Association between PMBMC public health · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Marital Failure and Subsequent Heart Failure: A Prospective Study.Journal of the American Heart Association · 2025
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Frontiers in psychology · 2025
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Janice K Kiecolt-GlaserInstitute for Behavioral Medicine Research, The Ohio State University College of Medicine.ORCID 0000-0003-4900-9578

Funding

Breast Cancer Survivors Cardiovascular Risks: Treatment and Behavioral InfluencesR01CA186720 · NCI · OHIO STATE UNIVERSITY · PI KIECOLT-GLASER, JANICE · 2014 to 2018
$4.6M
Marital quality and longevity: Biobehavioral pathwaysR01AG057032 · NIA · OHIO STATE UNIVERSITY · PI KIECOLT-GLASER, JANICE · 2017 to 2021
$3.2M
Aerobic Capacity, Depression, & Inflammatory Responsivity in Cancer SurvivorsR01CA186251 · NCI · OHIO STATE UNIVERSITY · PI KIECOLT-GLASER, JANICE · 2015 to 2019
$3.1M
Biobehavioral Influences on Cancer: Perspectives from PsychoneuroimmunologyK05CA172296 · NCI · OHIO STATE UNIVERSITY · PI KIECOLT-GLASER, JANICE · 2013 to 2017
$426k
NCI NIH HHS K05 CA172296NCI NIH HHS R01 CA186251NCI NIH HHS R01 CA186720NIA NIH HHS R01 AG057032
6 · The paper itself

Abstract

This article reviews evidence from several lines of work to describe how marriage and divorce can provoke health-relevant immune alterations, including ways that marital closeness can be perilous for health and divorce can be beneficial. The multiple stresses of a troubled relationship are depressogenic, and the development of a mood disorder sets the stage for psychological and biological vulnerability. Depression provides a central pathway to immune dysregulation, inflammation, and poor health; gender-related differences in depression and inflammation can heighten risk for women compared to men. Sleep and obesity can simultaneously feed off depression as they promote it. In addition, spousal similarities in health behaviors, gene expression, immune profiles and the gut microbiota offer new ways to consider the health advantages and risks of marriage and divorce, providing new perspectives on couples' interdependence, as well as new directions for research. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

Indexed as

Immune SystemDepressionDivorceHumansInflammationMarriageStress, Psychological

Identifiers

PMID30525786
PMCPMC6293993

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.