ArticleEpilepsia open2018
Running-down phenomenon captured with chronic electrocorticography.
Article in Epilepsia open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 16 citations in OpenAlex.
- The Tale of the Residual Tail: Insights From Continuous Intracranial Monitoring From Post-Hippocampectomy Dynamics.Annals of clinical and translational neurology · 2026Article
- Resolution of generalized tonic seizures following focal ablative or resective surgery.Epileptic disorders : international epilepsy journal with videotape · 2026Article
- Alteration of functional connectivity and network properties after stereo-electroencephalography guided radiofrequency thermocoagulation.Chinese neurosurgical journal · 2026Article
- Radiofrequency thermocoagulation for the treatment of refractory focal status epilepticus.Epileptic disorders : international epilepsy journal with videotape · 2025Article
- Chronic intracranial recordings after resection for epilepsy reveal a "running down" of epileptiform activity.Epilepsia · 2023Article
- Secondary Epileptogenesis: Common to See, but Possible to Treat?Frontiers in neurology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The running-down phenomenon refers to 2 analogous but distinct entities that may be seen after epilepsy surgery. The first is clinical, and denotes a progressive diminution in seizures after epilepsy surgery in which the epileptogenic zone could not be completely removed (Modern Problems of Psychopharmacology 1970;4:306, Brain 1996:989). The second is electrographic, and refers to a progressive deactivation of a secondary seizure focus after removal of the primary epileptogenic zone. This progressive decrease in epileptiform activity may represent a reversal of secondary epileptogenesis, where a primary epileptogenic zone is postulated to activate epileptiform discharges at a second site and may become independent.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.