ReviewFrontiers in chemistry2018
Post-Ugi Cyclization for the Construction of Diverse Heterocyclic Compounds: Recent Updates.
Review in Frontiers in chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Systematic Expansion of an Ugi-Based Multicomponent Synthesis of Tetrasubstituted Imidazoles.ACS omega · 2026Article
- α-Ketoglutaric acid in Ugi reactions and Ugi/aza-Wittig tandem reactions.Beilstein journal of organic chemistry · 2025Article
- Silver(I) triflate-catalyzed post-Ugi synthesis of pyrazolodiazepines.Beilstein journal of organic chemistry · 2025Article
- Isocyanate-based multicomponent reactions.RSC advances · 2024Review
- Ugi 5-center-4-component reaction of α-amino aldehydes and its application in synthesis of 2-oxopiperazines.Molecular diversity · 2024Article
- Curation and cheminformatics analysis of a Ugi-reaction derived library (URDL) of synthetically tractable small molecules for virtual screening application.Molecular diversity · 2024Article
- Multicomponent reactions driving the discovery and optimization of agents targeting central nervous system pathologies.Beilstein journal of organic chemistry · 2024Review
- Highly regioselective and diastereoselective synthesis of novel pyrazinoindolonesRSC advances · 2023Article
- Amide Bonds Meet Flow Chemistry: A Journey into Methodologies and Sustainable Evolution.ChemSusChem · 2022Review
- Coupling Interrupted Fischer and Multicomponent Joullié-Ugi to Chase Chemical Diversity: from Batch to Sustainable Flow Synthesis of Peptidomimetics.ChemMedChem · 2021Article
- Diastereoselective, Multicomponent Synthesis of Pyrrolopyrazinoquinazolinones via a Tandem Quinazolinone Rearrangement/Intramolecular Ring Closure of Tautomeric (Organic letters · 2021Article
- Three-Component Reactions of 3-Arylidene-3Molecules (Basel, Switzerland) · 2021Article
- Effective microwave-assisted approach to 1,2,3-triazolobenzodiazepinones via tandem Ugi reaction/catalyst-free intramolecular azide-alkyne cycloaddition.Beilstein journal of organic chemistry · 2021Article
- Copper (triazole-5-yl)methanamine complexes onto MCM-41: the synthesis of pyridine-containing pseudopeptides through the 6-RSC advances · 2020Article
- Controlling the stereochemistry in 2-oxo-aldehyde-derived Ugi adducts through the cinchona alkaloid-promoted electrophilic fluorination.Beilstein journal of organic chemistry · 2020Article
- Development of Novel and Efficient Processes for the Synthesis of 5-Amino and 5-Iminoimidazo[1,2-Frontiers in chemistry · 2019Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multicomponent reactions (MCRs) have proved as a valuable tool for organic and medicinal chemist because of their ability to introduce a large degree of chemical diversity in the product in a single step and with high atom economy. One of the dominant MCRs is the Ugi reaction, which involves the condensation of an aldehyde (or ketone), an amine, an isonitrile, and a carboxylic acid to afford an α-acylamino carboxamide adduct. The desired Ugi-adducts may be constructed by careful selection of the building blocks, opening the door for desired post-Ugi modifications. In recent times, the post-Ugi transformation has proved an important synthetic protocol to provide a variety of heterocyclic compounds with diverse biological properties. In this review, we have discussed the significant advancements reported in the recent literature with the emphasis to highlight the concepts and synthetic applications of the derived products along with critical mechanistic aspects.
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