Evidence map›Paper›PMID 30524965›Full record

ArticleFrontiers in oncology2018

SIRT6 Is Involved in the Progression of Ovarian Carcinomas via β-Catenin-Mediated Epithelial to Mesenchymal Transition.

Jun Sang Bae, Sang Jae Noh, Kyoung Min Kim, See-Hyoung Park, Usama Khamis Hussein, Ho Sung Park, Byung-Hyun Park, Sang Hoon Ha, Ho Lee, Myoung Ja Chung and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 50 citations in OpenAlex.

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  16. Ovarian Cancer Stem Cells: Characterization and Role in Tumorigenesis.Advances in experimental medicine and biology · 2021
    Article
  17. Review
  18. Article
  19. NAD metabolism in aging and cancer.Experimental biology and medicine (Maywood, N.J.) · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Jun Sang BaeDepartment of Pathology, Chonbuk National University Medical School, Chonbuk National University, Jeonju, South Korea.
Sang Jae NohResearch Institute for Clinical Medicine, Chonbuk National University, Jeonju, South Korea.
Kyoung Min KimDepartment of Pathology, Chonbuk National University Medical School, Chonbuk National University, Jeonju, South Korea.
See-Hyoung ParkDepartment of Bio and Chemical Engineering, Hongik University, Sejong, South Korea.
Usama Khamis HusseinDepartment of Pathology, Chonbuk National University Medical School, Chonbuk National University, Jeonju, South Korea.
Ho Sung ParkDepartment of Pathology, Chonbuk National University Medical School, Chonbuk National University, Jeonju, South Korea.
Byung-Hyun ParkDepartment of Biochemistry, Chonbuk National University Medical School, Chonbuk National University, Jeonju, South Korea.
Sang Hoon HaDivision of Biotechnology, Chonbuk National University, Iksan, South Korea.
Ho LeeDepartment of Forensic Medicine, Chonbuk National University Medical School, Chonbuk National University, Jeonju, South Korea.
Myoung Ja ChungDepartment of Pathology, Chonbuk National University Medical School, Chonbuk National University, Jeonju, South Korea.
Woo Sung MoonDepartment of Pathology, Chonbuk National University Medical School, Chonbuk National University, Jeonju, South Korea.
Dong Hyu ChoBiomedical Research Institute, Chonbuk National University Hospital, Jeonju, South Korea.
Kyu Yun JangDepartment of Pathology, Chonbuk National University Medical School, Chonbuk National University, Jeonju, South Korea.
Jeonbuk National University · KRJeonbuk National University Hospital · KRHongik University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SIRT6 is involved in various cellular signaling pathways including those involved in tumorigenesis in association with β-catenin. However, the role of SIRT6 in tumorigenesis has been controversially reported and the studies on the role of SIRT6 in ovarian cancers is limited. In this study, we evaluated the expression and roles of SIRT6 in conjunction with the expression of active β-catenin in 104 human ovarian carcinomas and ovarian cancer cells. In human ovarian carcinomas, the expressions of SIRT6 and active β-catenin were associated with higher tumor stage, higher histologic grade, and platinum-resistance. Moreover, nuclear expression of SIRT6 (104 ovarian carcinomas;

Indexed as

carcinomaovaryprognosisSIRT6β-catenin

Identifiers

PMID30524965
PMCPMC6256124
OpenAlexW2901962295

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.