Evidence map›Paper›PMID 30524956›Full record

ArticleFrontiers in oncology2018

The Comparative Treatment of Intraventricular Chemotherapy by Ommaya Reservoir vs. Lumbar Puncture in Patients With Leptomeningeal Carcinomatosis.

Mariano Montes de Oca Delgado, Bernardo Cacho Díaz, José Santos Zambrano, Vicente Guerrero Juárez, Manuel Salvador López Martínez, Elvira Castro Martínez, Javier Avendaño Méndez-Padilla, Sonia Mejía Pérez, Ignacio Reyes Moreno, Axayacatl Gutiérrez Aceves and 1 more

2 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06399926 recruitingnot on this mapstarted 2023, after this paper: background citation

A Open-label, Random, Multi-central Prospective Cohort of Observation Study on the Efficacy and Safety of Intraventricule Pemetrexed Disodium Via Ommaya Reservoir

TypeobservationalSponsorXiangya Hospital of Central South UniversityRan2023 to 2027Enrolled64ConditionsLeptomeningeal Metastasis, Lung CancerArmsPemetrexed injection, Pemetrexed
NCT07551414 phase2not yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Prospective Study of Zorifertinib Plus Intra-Ommaya CSF Chemotherapy for Leptomeningeal Progression in NSCLC After Third-Generation EGFR-TKI Therapy

TypeinterventionalSponsorCancer Institute and Hospital, Chinese Academy of Medical SciencesRan2026 to 2028Enrolled38ConditionsNSCLC (Non-small Cell Lung Carcinoma), Leptomeningeal Metastasis, EGFR-TKI Sensitizing Mutation, ZorifertinibArmsZorifertinib Plus Intra-Ommaya CSF Chemotherapy
3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Leptomeningeal Disease: Current Approaches and Future Directions.Current neurology and neuroscience reports · 2025
    Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Mariano Montes de Oca DelgadoEmergency Department, National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez" (INNN), Mexico City, Mexico.
Bernardo Cacho DíazNeuroscience Unit, National Cancer Institute, Mexico City, Mexico.
José Santos ZambranoEmergency Department, National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez" (INNN), Mexico City, Mexico.
Vicente Guerrero JuárezEmergency Department, National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez" (INNN), Mexico City, Mexico.
Manuel Salvador López MartínezEmergency Department, National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez" (INNN), Mexico City, Mexico.
Elvira Castro MartínezEmergency Department, National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez" (INNN), Mexico City, Mexico.
Javier Avendaño Méndez-PadillaNeurosurgery Department, National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez" (INNN), Mexico City, Mexico.
Sonia Mejía PérezNeurosurgery Department, National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez" (INNN), Mexico City, Mexico.
Ignacio Reyes MorenoNeurological Service, The American British Cowdray Medical Center, Mexico City, Mexico.
Axayacatl Gutiérrez AcevesNeurological Service, The American British Cowdray Medical Center, Mexico City, Mexico.
Alberto González AguilarEmergency Department, National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez" (INNN), Mexico City, Mexico.
Instituto Nacional de Neurología y Neurocirugía · MXCentro Médico ABC · MXInstituto Nacional de Cancerología · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

chemotherapyintraventricularkarnofsky performance statusleptomeningeal carcinomatosislumbar punctureommaya reservoiroverall survival

Identifiers

PMID30524956
PMCPMC6256195
OpenAlexW2901339782

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.