ReviewCurrent oral health reports2018
Oral Polymorphonuclear Neutrophil Contributes to Oral Health.
Review in Current oral health reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Mechanistic Characterization of Biologically Inspired Oral Neutrophil Isolation for AI-Assisted Oral Inflammatory Load Assessment.Biomimetics (Basel, Switzerland) · 2026Article
- Cytokine and chemokine dysregulation by microbial biofilm components: mechanisms and clinical implications.Archives of microbiology · 2026Review
- Salivary immune alteration persists after caries treatment.Scientific reports · 2026Article
- Histopathological Features and Clinical Findings of Feline Chronic Gingivostomatitis (FCGS) in Cats (Veterinary medicine international · 2026Article
- The Role of Reactive Oxygen Species (ROS) in Periodontitis: A Potential Therapeutic Target.Immunity, inflammation and disease · 2025Review
- Emerging therapeutic strategies targeting bone signaling pathways in periodontitis.Journal of periodontal research · 2025Review
- Antimicrobial Peptides: A Promising Alternative to Conventional Antimicrobials for Combating Polymicrobial Biofilms.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Toward Digital Periodontal Health: Recent Advances and Future Perspectives.Bioengineering (Basel, Switzerland) · 2024Review
- Neutrophils and neutrophil extracellular traps in oral health and disease.Experimental & molecular medicine · 2024Review
- The intriguing strategies ofFrontiers in oral health · 2024Article
- Understanding the functional relevance of oral neutrophils, phenotype and properties in OSCC.Medical oncology (Northwood, London, England) · 2023Review
- The Effect of Intensity-Modulated Radiotherapy to the Head and Neck Region on the Oral Innate Immune Response and Oral Microbiome: A Prospective Cohort Study of Head and Neck Tumour Patients.International journal of molecular sciences · 2022Article
- Host's Immunity andMicroorganisms · 2022Review
- Oral Cells-On-Chip: Design, Modeling and Experimental Results.Bioengineering (Basel, Switzerland) · 2022Article
- The Role of the Oral Immune System in Oropharyngeal Candidiasis-Facilitated Invasion and Dissemination ofFrontiers in oral health · 2022Review
- Increasing oral PMN during experimental gingivitis and its reversal by prophylaxis.Contemporary clinical trials communications · 2021Article
- LuxS quorum sensing system and biofilm formation of oral microflora: A short review article.The Saudi dental journal · 2021Review
- Immunomodulation in the Treatment of Periodontitis: Progress and Perspectives.Frontiers in immunology · 2021Review
- Innate Phagocyte Polarization in the Oral Cavity.Frontiers in immunology · 2021Review
- Interactions Between Neutrophils and Periodontal Pathogens in Late-Onset Periodontitis.Frontiers in cellular and infection microbiology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewOral health is maintained in a dynamic equilibrium between the host immunity and the oral microbiome. Oral polymorphonuclear neutrophils (oPMNs) are important innate immune cells in the oral cavity. RECENT
findingsThe oPMNs play a co-controlling part in the maintenance of oral equilibrium. In human saliva, the oPMNs integrity is preserved, and their function remains unaffected. In general, oPMNs are in a higher state of baseline activation compared to peripheral PMNs. However, in periodontitis, the oPMNs' activation state can result in excessive release of damaging molecules in the extracellular environment. SUMMARY: The presence of oPMNs may unwittingly negatively impact the integrity of the oral tissues. While most of the oPMN functions occur intracellularly, release of their potent active mediators into the extracellular environment may jeopardize oral homeostasis and its integrity. The dual nature of oPMNs, both beneficial and detrimental, remains a challenging and understudied topic.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.