ReviewMultidisciplinary respiratory medicine2018
From CPAP to tailored therapy for obstructive sleep Apnoea.
Review in Multidisciplinary respiratory medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Effects of heated humidification on positive airway pressure side effects in patients with obstructive sleep apnoea: a meta-analysis.Sleep & breathing = Schlaf & Atmung · 2023Pooled it
- Effects of telemedicine interventions in improving continuous positive airway pressure adherence in patients with obstructive sleep apnoea: a meta-analysis of randomised controlled trials.Sleep & breathing = Schlaf & Atmung · 2021Pooled it
- Pitolisant for Daytime Sleepiness in Patients with Obstructive Sleep Apnea Who Refuse Continuous Positive Airway Pressure Treatment. A Randomized Trial.American journal of respiratory and critical care medicine · 2020Trial
- Beyond hours per night: rethinking oral appliance adherence in OSA.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Article
- Quantification of ventilatory control in sleep apnea: from physiological insight to computable loop gain.Sleep · 2026Review
- Is barbed pharyngoplasty a suitable alternative to CPAP in OSA elderly patients?Sleep & breathing = Schlaf & Atmung · 2025Article
- Clinical phenotypes of obstructive sleep apnea in a sample of Saudi population.Sleep & breathing = Schlaf & Atmung · 2025Article
- Advancing Obstructive Sleep Apnea Management: Recent Trends from Conventional to Innovative Therapies.Journal of clinical medicine · 2025Review
- A comparative analysis of unsupervised machine-learning methods in PSG-related phenotyping.Journal of sleep research · 2025Article
- Sleep-Disordered Breathing and Cardiac Arrhythmias.Journal of clinical medicine · 2024Review
- Knowledge, attitude, and practice of inpatients with cardiovascular disease regarding obstructive sleep apnea.Scientific reports · 2024Article
- Sleep Apnea and Heart Failure-Current State-of-The-Art.International journal of molecular sciences · 2024Review
- Predictive tools for nocturnal respiratory failure in patients with moderate and severe OSAS.Sleep & breathing = Schlaf & Atmung · 2023Article
- Development of a combination of noradrenergic and antimuscarinic drugs for the treatment of obstructive sleep apnea: Challenges and progress.Frontiers in sleep · 2023Review
- Sleep apnea endotypes: from the physiological laboratory to scalable polysomnographic measures.Frontiers in sleep · 2023Article
- Comorbidity clusters in patients with moderate-to-severe OSA.Sleep & breathing = Schlaf & Atmung · 2022Article
- Hidden Markov model segmentation to demarcate trajectories of residual apnoea-hypopnoea index in CPAP-treated sleep apnoea patients to personalize follow-up and prevent treatment failure.The EPMA journal · 2021Article
- Treatment usage patterns of oral appliances for obstructive sleep apnea over the first 60 days: a cluster analysis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021Article
- Defining obstructive sleep apnoea syndrome: a failure of semantic rules.Breathe (Sheffield, England) · 2021Review
- The Emerging Role of Drug-Induced Sleep Endoscopy in the Management of Obstructive Sleep Apnea.Clinical and experimental otorhinolaryngology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obstructive Sleep Apnoea (OSA) is a common sleep disorder that is associated with daytime symptoms and a range of comorbidity and mortality. Continuous Positive Airway Pressure (CPAP) therapy is highly efficacious at preventing OSA when in use and has long been the standard treatment for newly diagnosed patients. However, CPAP therapy has well recognised limitations in real world effectiveness due to issues with patient acceptance and suboptimal usage. There is a clear need to enhance OSA treatment strategies and options. Although there are a range of alternative treatments (e.g. weight loss, oral appliances, positional devices, surgery, and emerging therapies such as sedatives and oxygen), generally there are individual differences in efficacy and often OSA will not be completely eliminated. There is increasing recognition that OSA is a heterogeneous disorder in terms of risk factors, clinical presentation, pathophysiology and comorbidity. Better characterisation of OSA heterogeneity will enable tailored approaches to therapy to ensure treatment effectiveness. Tools to elucidate individual anatomical and pathophysiological phenotypes in clinical practice are receiving attention. Additionally, recognising patient preferences, treatment enhancement strategies and broader assessment of treatment effectiveness are part of tailoring therapy at the individual level. This review provides a narrative of current treatment approaches and limitations and the future potential for individual tailoring to enhance treatment effectiveness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.