ReviewIranian journal of basic medical sciences2018
Medicinal plants for gingivitis: a review of clinical trials.
Review in Iranian journal of basic medical sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Systematic review and meta-analysis on the effect of olive oil in the treatment of periodontal diseases.Frontiers in oral health · 2025Pooled it
- The Effects of Curcumin in the Treatment of Gingivitis: A Systematic Review of Clinical Trials.Advances in experimental medicine and biology · 2021Pooled it
- Pooled it
- Traditional medicine and natural product based therapeutics in gingivitis management and microbial interactions.Frontiers in antibiotics · 2026Review
- Phytotherapy in Pediatric Dentistry: A Narrative Review of Clinical Applications and Evidence.Children (Basel, Switzerland) · 2025Review
- Effect of Polyherbal Toothpaste on Dental Plaque, Gingivitis, and Salivary Antioxidant Levels: A Single-blind Randomized Controlled Trial.International journal of clinical pediatric dentistry · 2025Article
- Novel Mouth Rinse Displaying Analgesic and Anti-inflammatory Properties: AnAnti-inflammatory & anti-allergy agents in medicinal chemistry · 2025Article
- The Efficacy ofInternational journal of clinical pediatric dentistry · 2024Article
- Article
- GC-MS analysis, molecular docking, and pharmacokinetic studies of Multidentia crassa extracts' compounds for analgesic and anti-inflammatory activities in dentistry.Scientific reports · 2024Review
- Periodontitis Continuum: Antecedents, Triggers, Mediators, and Treatment Strategies.Current medicinal chemistry · 2024Review
- Ayurvedic Drug Triphala in Combination with Providone Iodine Mitigates Radiation-Induced Mucositis in Head and Neck Cancer Patients without Affecting the Tumor Response.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023Article
- A Randomized Double-Blind Clinical Trial Evaluates the Efficacy of Alternative Herbal Mouthwashes.Cureus · 2023Article
- Formulation and Characterization of Mucoadhesive Polymeric Films Containing Extracts of Taraxaci Folium and Matricariae Flos.Molecules (Basel, Switzerland) · 2023Article
- Development of a novel, entirely herbal-based mouthwash effective against common oral bacteria and SARS-CoV-2.BMC complementary medicine and therapies · 2023Article
- Therapeutic Potential of Standardized Extract ofACS omega · 2022Article
- Development and Evaluation of Thermosensitive Hydrogels with Binary Mixture ofInternational journal of molecular sciences · 2021Article
- Evaluation of Mouthwash ContainingPlants (Basel, Switzerland) · 2021Article
- Gan-Lu-Yin (Kanroin), Traditional Chinese Herbal Extracts, Reduces Osteoclast Differentiation In Vitro and Prevents Alveolar Bone Resorption in Rat Experimental PeriodontitisJournal of clinical medicine · 2021Article
- Inhibitory Effect ofMolecules (Basel, Switzerland) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesPeriodontal diseases are among prevalent oral health problems which may ultimately lead to severe complications in oral cavity. Herbal products can be designed as single or multicomponent preparations for better oral health. This study aims to review current clinical trials on the effectiveness of herbal products in gingivitis. MATERIALS AND
methodsElectronic databases, including PubMed, Scopus, ScienceDirect and Cochrane library were searched with the keywords "gingivitis" in the title/abstract and "plant/ extract/ herb" in the whole text for clinical trials on herbal treatments for gingivitis. Data were collected from 2000 until January 2018. Only papers with English full-texts were included in our study.
resultsHerbal medicines in the form of dentifrice, mouth rinse, gel, and gum were assessed in gingivitis via specific indices including plaque index, bleeding index, microbial count, and biomarkers of inflammation. Pomegranate, aloe, green tea, and miswak have a large body of evidence supporting their effectiveness in gingivitis. They could act via several mechanisms such as decrease in gingival inflammation and bleeding, inhibition of dental plaque formation, and improvement in different indices of oral hygiene. Some polyherbal formulations such as triphala were also significantly effective in managing gingivitis complications.
conclusionOur study supports the efficacy and safety of several medicinal plants for gingivitis; however, some plants do not have enough evidence due to the few number of clinical trials. Thus, future studies are mandatory for further confirmation of the efficacy of these medicinal plants.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.