Evidence map›Paper›PMID 30524659›Full record

ArticleOxidative medicine and cellular longevity2018

A Novel Small Peptide Inhibitor of NF

Jessica Gambardella, Michele Ciccarelli, Carmine Del Giudice, Antonella Fiordelisi, Matteo De Rosa, Marina Sala, Roberto Pacelli, Pietro Campiglia, Bruno Trimarco, Guido Iaccarino and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxidative medicine and cellular longevity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Oxidative Stress and Inflammation in Cancer.Antioxidants (Basel, Switzerland) · 2024
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Jessica GambardellaDepartment of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Via Salvatore Allende, 84081 Baronissi, Salerno, Italy.ORCID 0000-0001-5563-3153
Michele CiccarelliDepartment of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Via Salvatore Allende, 84081 Baronissi, Salerno, Italy.
Carmine Del GiudiceDepartment of Advanced Biomedical Sciences, Federico II University, Via Pansini 5, 80131 Naples, Italy.
Antonella FiordelisiDepartment of Advanced Biomedical Sciences, Federico II University, Via Pansini 5, 80131 Naples, Italy.
Matteo De RosaDepartment of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Via Salvatore Allende, 84081 Baronissi, Salerno, Italy.
Marina SalaDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, Salerno, Italy.ORCID 0000-0003-2739-7215
Roberto PacelliDepartment of Advanced Biomedical Sciences, Federico II University, Via Pansini 5, 80131 Naples, Italy.
Pietro CampigliaDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, Salerno, Italy.
Bruno TrimarcoDepartment of Advanced Biomedical Sciences, Federico II University, Via Pansini 5, 80131 Naples, Italy.ORCID 0000-0002-0701-6449
Guido IaccarinoDepartment of Advanced Biomedical Sciences, Federico II University, Via Pansini 5, 80131 Naples, Italy.ORCID 0000-0002-8997-835X
Daniela SorrientoDepartment of Advanced Biomedical Sciences, Federico II University, Via Pansini 5, 80131 Naples, Italy.ORCID 0000-0002-1599-4509
Federico II University Hospital · ITUniversity of Salerno · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe RH domain of GRK5 is an effective modulator of cancer growth through the inhibition of NF

methodsStarting from the RH sequence, small peptides were cloned and tested in KAT-4 cells. The effects on NF

resultsA minimum RH ten amino acids long sequence (RH10) was able to interact with I

conclusionOur data propose RH10 as a potential peptide-based drug to use for cancer treatment both alone or in combination with anticancer therapies.

Indexed as

AnimalsApoptosisCell ProliferationG-Protein-Coupled Receptor Kinase 5HumansMiceMice, Inbred BALB CMice, NudeNF-kappa BOxidative StressPeptide FragmentsPhenotypeProtein DomainsSignal TransductionThyroid NeoplasmsTumor Cells, CulturedG-Protein-Coupled Receptor Kinase 5Grk5 protein, mouseNF-kappa BPeptide Fragments

Identifiers

PMID30524659
PMCPMC6247396
OpenAlexW2899034185

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.