ReviewChinese medicine2018
Application of metabolomics in toxicity evaluation of traditional Chinese medicines.
Review in Chinese medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Multifunctional cardiac tropin I sensing using MWCNTs-COOH/PoPD composites for integrated warning, screening and protection assessment of traditional Chinese medicine-induced cardiotoxicity.Mikrochimica acta · 2026Article
- Metabolomics and Mechanistic Approaches Reveal the Synergistic and Attenuating of Rubus chingii Hu on Tripterygium Glycoside Tablets in the Treatment of Rheumatoid Arthritis.Chemistry & biodiversity · 2026Article
- Dynamic Chemical Profiling ofFoods (Basel, Switzerland) · 2026Article
- Dual modulation of toxic risks and functional benefits: How traditional practices enable safe consumption of toxicFrontiers in plant science · 2026Article
- Advances in Traditional Chinese Medicine for chronic obstructive pulmonary disease through multi-omics approaches.Frontiers in cell and developmental biology · 2026Review
- Metabolomic insights of cultured meat compared to conventional meat.Scientific reports · 2025Article
- Effect of freeze-pressure regulated extraction technology on the physicochemical properties and pharmacological activities of guizhi extract.Frontiers in chemistry · 2025Article
- Drug or Toxic? A Brief Understanding of the Edible Corolla ofMetabolites · 2024Article
- ToxDAR: A Workflow Software for Analyzing Toxicologically Relevant Proteomic and Transcriptomic Data, from Data Preparation to Toxicological Mechanism Elucidation.International journal of molecular sciences · 2024Article
- Review
- Crotonis Fructus-induced gut microbiota and serum metabolic disorders in rats.Applied microbiology and biotechnology · 2023Article
- Article
- Article
- Traditional Chinese Medicine Formula Jian Pi Tiao Gan Yin Reduces Obesity in Mice by Modulating the Gut Microbiota and Fecal Metabolism.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Identification of key pharmacodynamic markers of American ginseng against heart failure based on metabolomics and zebrafish model.Frontiers in pharmacology · 2022Article
- Potential cardiotoxicity induced by Euodiae Fructus:Frontiers in pharmacology · 2022Article
- Unravelling the Anticancer Mechanisms of Traditional Herbal Medicines with Metabolomics.Molecules (Basel, Switzerland) · 2021Review
- Identification of triptonide as a therapeutic agent for triple negative breast cancer treatment.Scientific reports · 2021Article
- Deciphering the mechanism of action of antitubercular compounds with metabolomics.Computational and structural biotechnology journal · 2021Review
- The Proteins of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS CoV-2 or n-COV19), the Cause of COVID-19.The protein journal · 2020Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Traditional Chinese medicines (TCM) have a long history of use because of its potential complementary therapy and fewer adverse effects. However, the toxicity and safety issues of TCM have drawn considerable attention in the past two decades. Metabolomics is an "omics" approach that aims to comprehensively analyze all metabolites in biological samples. In agreement with the holistic concept of TCM, metabolomics has shown great potential in efficacy and toxicity evaluation of TCM. Recently, a large amount of metabolomic researches have been devoted to exploring the mechanism of toxicity induced by TCM, such as hepatotoxicity, nephrotoxicity, and cardiotoxicity. In this paper, the application of metabolomics in toxicity evaluation of bioactive compounds, TCM extracts and TCM prescriptions are reviewed, and the potential problems and further perspectives for application of metabolomics in toxicological studies are also discussed.
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