ArticleFrontiers in immunology2018
Signatures of T and B Cell Development, Functional Responses and PD-1 Upregulation After HCMV Latent Infections and Reactivations in Nod.Rag.Gamma Mice Humanized With Cord Blood CD34
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Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
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Who cites it
25 citing papers in PubMed, 30 citations in OpenAlex.
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- Can Humanized Immune System Mouse and Rat Models Accelerate the Development of Cytomegalovirus-Based Vaccines Against Infectious Diseases and Cancers?International journal of molecular sciences · 2025Review
- Viral microRNA regulation of Akt is necessary for reactivation of Human Cytomegalovirus from latency in CD34+ hematopoietic progenitor cells and humanized mice.PLoS pathogens · 2024Article
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- Mouse Models for Human Herpesviruses.Pathogens (Basel, Switzerland) · 2023Review
- Recent Developments in NSG and NRG Humanized Mouse Models for Their Use in Viral and Immune Research.Viruses · 2023Review
- Companion diagnostic requirements for spatial biology using multiplex immunofluorescence and multispectral imaging.Frontiers in molecular biosciences · 2023Review
- Non-viralFrontiers in immunology · 2023Article
- Cytomegalovirus infection may be oncoprotective against neoplasms of B-lymphocyte lineage: single-institution experience and survey of global evidence.Virology journal · 2022Article
- A rapid, easy, and scalable whole blood monocyte CD169 assay for outpatient screening during SARS-CoV-2 outbreak, and potentially other emerging disease outbreaks.SAGE open medicine · 2022Article
- Immune Prophylaxis and Therapy for Human Cytomegalovirus Infection.International journal of molecular sciences · 2021Review
- In Vivo Lentiviral Gene Delivery of HLA-DR and Vaccination of Humanized Mice for Improving the Human T and B Cell Immune Reconstitution.Biomedicines · 2021Article
- CD169 and CD64 could help differentiate bacterial from CoVID-19 or other viral infections in the Emergency Department.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2021Observational
- Human cytomegalovirus infection: A considerable issue following allogeneic hematopoietic stem cell transplantation.Oncology letters · 2021Review
- Development of a huBLT Mouse Model to Study HCMV Latency, Reactivation, and Immune Response.Methods in molecular biology (Clifton, N.J.) · 2021Article
- CAR-T Cells Targeting Epstein-Barr Virus gp350 Validated in a Humanized Mouse Model of EBV Infection and Lymphoproliferative Disease.Molecular therapy oncolytics · 2020Article
- Innovations, challenges, and minimal information for standardization of humanized mice.EMBO molecular medicine · 2020Review
- Repertoire characterization and validation of gB-specific human IgGs directly cloned from humanized mice vaccinated with dendritic cells and protected against HCMV.PLoS pathogens · 2020Article
Corrections and comments
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Authors and funding
23 authors at 9 institutions in 1 country.
Sebastian J TheobaldClinic of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.
Sahamoddin KhailaieDepartment of Systems Immunology and Braunschweig Integrated Centre of Systems Biology (BRICS), Helmholtz Centre for Infection Research, Braunschweig, Germany.
Michael Meyer-HermannDepartment of Systems Immunology and Braunschweig Integrated Centre of Systems Biology (BRICS), Helmholtz Centre for Infection Research, Braunschweig, Germany.
Valery VolkClinic of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.
Henning OlbrichClinic of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.
Simon DanischClinic of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.
Laura GeraschClinic of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.
Andreas SchneiderClinic of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.
Christian SinzgerInstitute of Virology, University of Ulm, Ulm, Germany.
Dirk SchaudienFraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Hannover, Germany.
Stefan LienenklausInstitute for Laboratory Animal Science, Hannover Medical School, Hannover, Germany.
Peggy RieseDepartment of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research Braunschweig, Braunschweig, Germany.
Carlos A GuzmanDepartment of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research Braunschweig, Braunschweig, Germany.
Constanca FigueiredoDepartment of Transfusion Medicine, Hannover Medical School, Hannover, Germany.
Constantin von KaisenbergClinic of Gynecology and Obstetrics, Hannover Medical School, Hannover, Germany.
Loukia M SpineliInstitute for Biostatistics, Hannover Medical School, Hannover, Germany.
Stephanie GlaesenerClinic of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.
Almut Meyer-BahlburgDepartment of Pediatrics, University Medicine Greifswald, Greifswald, Germany.
Arnold GanserClinic of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.
Michael SchmittDepartment of Hematology, Oncology and Rheumatology, GMP Core Facility, Heidelberg University Hospital, Heidelberg, Germany.
Michael MachInstitute of Virology, University Erlangen-Nürnberg, Erlangen, Germany.
Martin MesserlePartner Site Hannover-Braunschweig, German Center for Infection Research (DZIF), Braunschweig, Germany.
Renata StripeckeClinic of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.
Medizinische Hochschule Hannover · DEHelmholtz Centre for Infection Research · DEFraunhofer Institute for Toxicology and Experimental Medicine · DEFriedrich-Alexander-Universität Erlangen-Nürnberg · DEGerman Center for Infection Research · DEHeidelberg University · DETechnische Universität Braunschweig · DEUniversitätsmedizin Greifswald · DEUniversität Ulm · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human cytomegalovirus (HCMV) latency is typically harmless but reactivation can be largely detrimental to immune compromised hosts. We modeled latency and reactivation using a traceable HCMV laboratory strain expressing the
Indexed as
AnimalsB-LymphocytesCord Blood Stem Cell TransplantationCytomegalovirusCytomegalovirus InfectionsFetal BloodHEK293 CellsHeterograftsHumansMiceProgrammed Cell Death 1 ReceptorT-LymphocytesUp-RegulationVirus ActivationVirus LatencyPDCD1 protein, humanProgrammed Cell Death 1 ReceptorB cell class switchHCMVhumanized micelinear discriminant analysesoptical imaging analysesprincipal component analysesreactivationT cell maturation
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.