Evidence map›Paper›PMID 30524444›Full record

ArticleFrontiers in immunology2018

Myocarditis Elicits Dendritic Cell and Monocyte Infiltration in the Heart and Self-Antigen Presentation by Conventional Type 2 Dendritic Cells.

Katrien Van der Borght, Charlotte L Scott, Liesbet Martens, Dorine Sichien, Gert Van Isterdael, Veronika Nindl, Yvan Saeys, Louis Boon, Burkhard Ludewig, Thierry C Gillebert and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 38 citations in OpenAlex.

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  8. Cardiomyocyte β-arrestins mediate inflammation and cGAS-STING activation in CVB3 viral myocarditis.American journal of physiology. Heart and circulatory physiology · 2026
    Article
  9. Immunometabolism in heart failure.Nature reviews. Cardiology · 2025
    Review
  10. Interferon gamma signaling drives cardiac metabolic rewiring.bioRxiv : the preprint server for biology · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Katrien Van der BorghtImmunoregulation and Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent, Belgium.
Charlotte L ScottImmunoregulation and Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent, Belgium.
Liesbet MartensImmunoregulation and Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent, Belgium.
Dorine SichienImmunoregulation and Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent, Belgium.
Gert Van IsterdaelImmunoregulation and Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent, Belgium.
Veronika NindlInstitute of Immunobiology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
Yvan SaeysImmunoregulation and Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent, Belgium.
Louis BoonBioceros, Utrecht, Netherlands.
Burkhard LudewigInstitute of Immunobiology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
Thierry C GillebertDepartment of Internal Medicine, Ghent University, Ghent, Belgium.
Bart N LambrechtImmunoregulation and Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent, Belgium.
Ghent University · BEKantonsspital St. Gallen · CHVIB-UGent Center for Inflammation Research · BEErasmus University Rotterdam · NLPolpharma Biologics (Netherlands) · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autoimmune myocarditis often leads to dilated cardiomyopathy (DCM). Although T cell reactivity to cardiac self-antigen is common in the disease, it is unknown which antigen presenting cell (APC) triggers autoimmunity. Experimental autoimmune myocarditis (EAM) was induced by immunizing mice with α-myosin loaded bone marrow APCs cultured in GM-CSF. APCs found in such cultures include conventional type 2 CD11b

Indexed as

Antigen PresentationAutoantigensAutoimmune DiseasesMyocarditisAnimalsCardiomyopathy, DilatedCell DifferentiationDendritic CellsMiceMice, Inbred BALB CMice, TransgenicMonocytesTh17 CellsTh1 CellsAutoantigensautoimmunityautoreactive T cellsdendritic cellsheart failuremyocarditis

Identifiers

PMID30524444
PMCPMC6258766
OpenAlexW2901299602

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.