Evidence map›Paper›PMID 30524368›Full record

ArticleFrontiers in endocrinology2018

Metabolic and Cognitive Outcomes of Subchronic Once-Daily Intranasal Insulin Administration in Healthy Men.

Yvonne Ritze, Werner Kern, Eva-Maria Ebner, Serena Jahn, Christian Benedict, Manfred Hallschmid

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Yvonne RitzeDepartment of Medical Psychology and Behavioral Neurobiology, University of Tübingen, Tübingen, Germany.
Werner KernEndokrinologikum Ulm, Ulm, Germany.
Eva-Maria EbnerDepartment of Medical Psychology and Behavioral Neurobiology, University of Tübingen, Tübingen, Germany.
Serena JahnDepartment of Medical Psychology and Behavioral Neurobiology, University of Tübingen, Tübingen, Germany.
Christian BenedictDepartment of Neuroscience, Uppsala University, Uppsala, Sweden.
Manfred HallschmidDepartment of Medical Psychology and Behavioral Neurobiology, University of Tübingen, Tübingen, Germany.
University of Tübingen · DEEndokrinologikum · DEHeinrich Heine University Düsseldorf · DEUniversity of Lübeck · DEUppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Insulin acts in the brain to limit food intake and improve memory function. We have previously shown that 8 weeks of intranasal insulin delivered in four daily doses of 40 IU decrease body weight and enhance word list recall. In the present study, we investigated the effect on body composition, endocrine parameters, and memory performance of 8 weeks of once-daily administration of 160 IU in healthy men. We assumed that intranasal insulin administered before nocturnal sleep, a period of relative metabolic inactivity that moreover benefits memory formation, would be superior to insulin delivery in the morning and placebo administration. After a 2-week baseline period, healthy male normal-weight subjects (mean age, 27.1 ± 0.9 years) received either placebo, 160 IU intranasal insulin in the morning, or 160 IU in the evening (

Indexed as

body compositioncognitive functionendocrine parametersintranasal insulinmetabolism

Identifiers

PMID30524368
PMCPMC6262365
OpenAlexW2898382268

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.