Evidence map›Paper›PMID 30524266›Full record

ArticleFrontiers in aging neuroscience2018

Targeted Mutation (R100W) of the Gene Encoding NGF Leads to Deficits in the Peripheral Sensory Nervous System.

Wanlin Yang, Kijung Sung, Fengli Zhou, Wei Xu, Robert A Rissman, Jianqing Ding, Chengbiao Wu

Open access · goldAbstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Herbal Prescription SH003 Alleviates Docetaxel-Induced Neuropathic Pain in C57BL/6 Mice.Evidence-based complementary and alternative medicine : eCAM · 2021
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Wanlin YangDepartment of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Kijung SungDepartment of Neurosciences, University of California, San Diego, San Diego, CA, United States.
Fengli ZhouDepartment of Respiratory Medicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Wei XuDepartment of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Robert A RissmanDepartment of Neurosciences, University of California, San Diego, San Diego, CA, United States.
Jianqing DingDepartment of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chengbiao WuDepartment of Neurosciences, University of California, San Diego, San Diego, CA, United States.
University of California, San Diego · USShanghai Jiao Tong University · CNRuijin Hospital · CNThird Affiliated Hospital of Sun Yat-sen University · CN

Funding

B-Synuclein as a Treatment for Lewy Body DiseaseR01AG018440 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RISSMAN, ROBERT · 2001 to 2021
$5.2M
Proinflammatory Endophenotype to predict NSAID treatment response Alzheimer's trialsR01AG051848 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI LYKETSOS, CONSTANTINE G, O'BRYANT, SID E · 2016 to 2020
$3.7M
a-synuclein clearance strategies for the treatment of Lewy body disease.R37AG018440 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MASLIAH, ELIEZER · 2006 to 2014
$2.7M
Pathogenicity of neuronally-derived tau in exosomesR21AG051839 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RISSMAN, ROBERT · 2016 to 2017
$426k
BLRD VA I01 BX003040NIA NIH HHS R01 AG018440NIA NIH HHS R01 AG051848NIA NIH HHS R21 AG051839NIA NIH HHS R37 AG018440
6 · The paper itself

Abstract

Nerve growth factor (NGF) exerts multifaceted functions through different stages of life. A missense mutation (R100W) in the beta-NGF gene was found in hereditary sensory autonomic neuropathy V (HSAN V) patients with severe loss of pain perception but without overt cognitive impairment. To better understand the pathogenesis of HSAN V, we generated the first NGF

Indexed as

hereditary sensory autonomic neuropathy VIntraepidermal Nerve Fibernerve growth factorp75 neurotrophic factor receptorTrkA

Identifiers

PMID30524266
PMCPMC6262302
OpenAlexW2901240556

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.