ArticleFrontiers in human neuroscience2018
Watch, Imagine, Attempt: Motor Cortex Single-Unit Activity Reveals Context-Dependent Movement Encoding in Humans With Tetraplegia.
Article in Frontiers in human neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00912041 (BrainGate2), which is not on this map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia
Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- Observation-related activity in the human motor cortex increases with effector anthropomorphicity.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Hierarchical and context-dependent encoding of actions in human posterior parietal and motor cortex.Cell · 2026Article
- Limb state accounts for differences between motor imagery and action in motor cortex.medRxiv : the preprint server for health sciences · 2026Article
- Human motor cortex encodes complex handwriting through a sequence of stable neural states.Nature human behaviour · 2025Article
- Article
- Neural signal analysis in chronic stroke: advancing intracortical brain-computer interface design.Frontiers in human neuroscience · 2025Article
- Modulation of vigilance/alertness using beta (30 Hz) transcranial alternating current stimulation.Frontiers in neuroscience · 2025Article
- Motor cortex retains and reorients neural dynamics during motor imagery.Nature human behaviour · 2024Article
- An Investigation of Manifold-Based Direct Control for a Brain-to-Body Neural Bypass.IEEE open journal of engineering in medicine and biology · 2024Article
- Spelling interface using intracortical signals in a completely locked-in patient enabled via auditory neurofeedback training.Nature communications · 2022Article
- Human brain mapping with multithousand-channel PtNRGrids resolves spatiotemporal dynamics.Science translational medicine · 2022Article
- Feel Your Reach: An EEG-Based Framework to Continuously Detect Goal-Directed Movements and Error Processing to Gate Kinesthetic Feedback Informed Artificial Arm Control.Frontiers in human neuroscience · 2022Review
- Neuromotor prosthetic to treat stroke-related paresis: N-of-1 trial.Communications medicine · 2022Article
- Review
- Intracortical Microelectrode Array Unit Yield under Chronic Conditions: A Comparative Evaluation.Micromachines · 2021Review
- Auditory cues reveal intended movement information in middle frontal gyrus neuronal ensemble activity of a person with tetraplegia.Scientific reports · 2021Article
- Spatial-temporal aspects of continuous EEG-based neurorobotic control.Journal of neural engineering · 2020Article
- Causes and consequences of representational drift.Current opinion in neurobiology · 2019Review
- Article
- The Neural Representation of Force across Grasp Types in Motor Cortex of Humans with Tetraplegia.eNeuroArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 7 institutions in 1 country.
Funding
Abstract
Planning and performing volitional movement engages widespread networks in the human brain, with motor cortex considered critical to the performance of skilled limb actions. Motor cortex is also engaged when actions are observed or imagined, but the manner in which ensembles of neurons represent these volitional states (VoSs) is unknown. Here we provide direct demonstration that observing, imagining or attempting action activates shared neural ensembles in human motor cortex. Two individuals with tetraplegia (due to brainstem stroke or amyotrophic lateral sclerosis, ALS) were verbally instructed to watch, imagine, or attempt reaching actions displayed on a computer screen. Neural activity in the precentral gyrus incorporated information about both cognitive state and movement kinematics; the three conditions presented overlapping but unique, statistically distinct activity patterns. These findings demonstrate that individual neurons in human motor cortex reflect information related to sensory inputs and VoS in addition to movement features, and are a key part of a broader network linking perception and cognition to action.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.