Evidence map›Paper›PMID 30524248›Full record

ArticleFrontiers in neural circuits2018

A Pipeline for Volume Electron Microscopy of the

Ben Mulcahy, Daniel Witvliet, Douglas Holmyard, James Mitchell, Andrew D Chisholm, Yaron Meirovitch, Aravinthan D T Samuel, Mei Zhen

Erratum issuedAbstract read
In one paragraph

Article in Frontiers in neural circuits, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. RAEM: random-access electron microscopy for revisitable 3D imaging.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Volume electron microscopy.Nature reviews. Methods primers · 2022
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Ben MulcahyLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
Daniel WitvlietLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
Douglas HolmyardDepartment of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada.
James MitchellCenter for Brain Science, Department of Physics, Harvard University, Cambridge, MA, United States.
Andrew D ChisholmSection of Cell and Developmental Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA, United States.
Yaron MeirovitchDepartment of Physiology, University of Toronto, Toronto, ON, Canada.
Aravinthan D T SamuelCenter for Brain Science, Department of Physics, Harvard University, Cambridge, MA, United States.
Mei ZhenLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.

Funding

Center for C elegans AnatomyR24OD010943 · OD · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI DAVID H. HALL, Nathan Schroeder · 2012 to 2026
$9.6M
Mechanisms of Tissue Morphogenesis in C. elegansR01GM054657 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI CHISHOLM, ANDREW D · 1997 to 2018
$5.8M
Sensory-motor processing in a developing nervous systemR01NS082525 · NINDS · HARVARD UNIVERSITY · PI ALKEMA, MARK, LICHTMAN, JEFF W · 2015 to 2018
$2.3M
CIHR MOP123250CIHR MOP93619NIGMS NIH HHS R01 GM054657NIH HHS R24 OD010943NINDS NIH HHS R01 NS082525
6 · The paper itself

Abstract

The "connectome," a comprehensive wiring diagram of synaptic connectivity, is achieved through volume electron microscopy (vEM) analysis of an entire nervous system and all associated non-neuronal tissues. White et al. (1986) pioneered the fully manual reconstruction of a connectome using

Indexed as

AnimalsCaenorhabditis elegansConnectomeMicroscopy, ElectronNerve NetNervous SystemVitrificationC. elegansconnectomehigh-pressure freezingnervous systemvolume electron microscopy

Identifiers

PMID30524248
PMCPMC6262311

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.