ArticleFrontiers in neuroscience2018
Phoenixin Expression Is Regulated by the Fatty Acids Palmitate, Docosahexaenoic Acid and Oleate, and the Endocrine Disrupting Chemical Bisphenol A in Immortalized Hypothalamic Neurons.
Article in Frontiers in neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- Central administration of docosahexaenoic acid, eicosapentaenoic acid, or linoleic acid activates hypothalamic fatty acid sensing and is involved in reproductive regulation in spotted scat (Scatophagus argus).Fish physiology and biochemistry · 2025Article
- Elevated serum phoenixin levels in boys with central precocious puberty are positively correlated with BMI.Endocrine connections · 2025Article
- Relationship between high-fat diet, gut microbiota, and precocious puberty: mechanisms and implications.Frontiers in microbiology · 2025Review
- High-fat diet-induced obesity accelerates puberty in male rats through SMIM20/phoenixin upregulation.Frontiers in endocrinology · 2025Article
- Childhood Obesity, Hypothalamic Inflammation, and the Onset of Puberty: A Narrative Review.Nutrients · 2024Review
- Phoenixin-14 as a novel direct regulator of porcine luteal cell functions†.Biology of reproduction · 2024Article
- A systematic scoping review of the multifaceted role of phoenixin in metabolism: insights fromFrontiers in endocrinology · 2024Article
- The Levels of Phoenixin-14 and Phoenixin-20 in Patients with Type 2 Diabetes Mellitus.Endocrine, metabolic & immune disorders drug targets · 2024Article
- Article
- Links between Childhood Obesity, High-Fat Diet, and Central Precocious Puberty.Children (Basel, Switzerland) · 2023Review
- Current state of phoenixin-the implications of the pleiotropic peptide in stress and its potential as a therapeutic target.Frontiers in pharmacology · 2023Review
- The Regulation of Phoenixin: A Fascinating Multidimensional Peptide.Journal of the Endocrine Society · 2022Review
- Regulation and physiological functions of phoenixin.Frontiers in molecular biosciences · 2022Review
- Review
- Diet-Induced Hypothalamic Inflammation, Phoenixin, and Subsequent Precocious Puberty.Nutrients · 2021Review
- Phoenixin: More than Reproductive Peptide.International journal of molecular sciences · 2020Review
- Neuropeptides in gut-brain axis and their influence on host immunity and stress.Computational and structural biotechnology journal · 2020Review
- Phoenixin 14 Inhibits High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Experimental Mice.Drug design, development and therapy · 2020Article
- Neuro-toxic and Reproductive Effects of BPA.Current neuropharmacology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phoenixin (PNX) is a newly identified reproductive peptide required for the estrous cycle. It is most highly expressed in the hypothalamus, where it is a positive regulator of gonadotropin-releasing hormone (GnRH) and kisspeptin. However, it is unknown what signals lie upstream of
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.