ArticleNatural computing2018
Computing with biological switches and clocks.
Article in Natural computing, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed.
- Complexity reduction by symmetry: Uncovering the minimal regulatory network for logical computation in bacteria.PLoS computational biology · 2025Article
- Dynamics and bifurcations in genetic circuits with fibration symmetries.Journal of the Royal Society, Interface · 2024Article
- Emergent digital bio-computation through spatial diffusion and engineered bacteria.Nature communications · 2024Article
- Article
- Disruption in the regulation of casein kinase 2 in circadian rhythm leads to pathological states: cancer, diabetes and neurodegenerative disorders.Frontiers in molecular neuroscience · 2023Article
- Programmable synthetic cell networks regulated by tuneable reaction rates.Nature communications · 2022Article
- Programming Molecular Systems To Emulate a Learning Spiking Neuron.ACS synthetic biology · 2022Article
- Robust finite automata in stochastic chemical reaction networks.Royal Society open science · 2021Article
- A modular approach for modeling the cell cycle based on functional response curves.PLoS computational biology · 2021Article
- Translational control of enzyme scavenger expression with toxin-induced micro RNA switches.Scientific reports · 2021Article
- Nanobody-mediated control of gene expression and epigenetic memory.Nature communications · 2021Article
- Synthesizing AND gate minigene circuits based on CRISPReader for identification of bladder cancer cells.Nature communications · 2020Article
- Engineered signal-coupled inducible promoters: measuring the apparent RNA-polymerase resource budget.Nucleic acids research · 2020Article
- Circuits with broken fibration symmetries perform core logic computations in biological networks.PLoS computational biology · 2020Article
- From Microbial Communities to Distributed Computing Systems.Frontiers in bioengineering and biotechnology · 2020Review
- An Inactivation Switch Enables Rhythms in aInternational journal of molecular sciences · 2019Article
- Computational modelling unravels the precise clockwork of cyanobacteria.Interface focus · 2018Review
- Towards an Aspect-Oriented Design and Modelling Framework for Synthetic Biology.Processes (Basel, Switzerland) · 2018Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The complex dynamics of biological systems is primarily driven by molecular interactions that underpin the regulatory networks of cells. These networks typically contain positive and negative feedback loops, which are responsible for switch-like and oscillatory dynamics, respectively. Many computing systems rely on switches and clocks as computational modules. While the combination of such modules in biological systems leads to a variety of dynamical behaviours, it is also driving development of new computing algorithms. Here we present a historical perspective on computation by biological systems, with a focus on switches and clocks, and discuss parallels between biology and computing. We also outline our vision for the future of biological computing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.