Trial reportJSLS : Journal of the Society of Laparoendoscopic Surgeons
Efficacy of a New Crosslinked Hyaluronan Gel in the Prevention of Intrauterine Adhesions.
Trial report in JSLS : Journal of the Society of Laparoendoscopic Surgeons. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Study on Risk Factors Related to Intrauterine Adhesion Based on Meta-Analysis.Computational and mathematical methods in medicine · 2022Pooled it
- Engineering Hydrogels for Intrauterine Adhesion Therapy and Endometrial Regeneration.Gels (Basel, Switzerland) · 2026Review
- Pregnancy outcomes following hysteroscopic myomectomy in infertile patients with FIGO type 0-II fibroids: a retrospective study.Frontiers in medicine · 2026Article
- Platelet Count and Platelet Hematocrit Correlate to the Occurrence and Postoperative Recurrence in Intrauterine Adhesion Patients.International journal of women's health · 2025Article
- The Application of Hydrogels in the Treatment of Intrauterine Adhesions.Current pharmaceutical design · 2025Review
- LncRNA MALAT1 Knockdown Alleviates Fibrogenic Response in Human Endometrial Stromal Cells Via the miR-22-3p/TGFβR1/Smad2/3 Pathway.Cell biochemistry and biophysics · 2024Article
- Article
- Amorphous curcumin-based hydrogels to reduce the incidence of post-surgical intrauterine adhesions.Regenerative biomaterials · 2024Article
- Cyclical endometrial repair and regeneration: Molecular mechanisms, diseases, and therapeutic interventions.MedComm · 2023Review
- Techniques for navigating postsurgical adhesions: Insights into mechanisms and future directions.Bioengineering & translational medicine · 2023Review
- Effect of hysteroscopic adhesiolysis on recurrence, menstruation and pregnancy outcomes in patients with different degrees of intrauterine adhesions.American journal of translational research · 2022Article
- Recent Developments in Biomaterial-Based Hydrogel as the Delivery System for Repairing Endometrial Injury.Frontiers in bioengineering and biotechnology · 2022Review
- Recent progress of Bioinspired Hydrogel-based delivery system for endometrial repair.Frontiers in bioengineering and biotechnology · 2022Review
- Recent trends in therapeutic strategies for repairing endometrial tissue in intrauterine adhesion.Biomaterials research · 2021Review
- Prevention of Post-Operative Adhesions: A Comprehensive Review of Present and Emerging Strategies.Biomolecules · 2021Review
- Focus on the Primary Prevention of Intrauterine Adhesions: Current Concept and Vision.International journal of molecular sciences · 2021Review
- Application of Bioactive Hydrogels for Functional Treatment of Intrauterine Adhesion.Frontiers in bioengineering and biotechnology · 2021Review
- Crosslinked Hyaluronic Acid Gels for the Prevention of Intrauterine Adhesions after a Hysteroscopic Myomectomy in Women with Submucosal Myomas: A Prospective, Randomized, Controlled Trial.Life (Basel, Switzerland) · 2020Article
- Comparison of Autocross-Linked Hyaluronic Acid Gel and Intrauterine Device for Preventing Intrauterine Adhesions in Infertile Patients: A Randomized Clinical Trial.Gynecology and minimally invasive therapyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesThe authors sought to assess the effect of the use of a new crosslinked hyaluronan (NCH) gel on the prevention of intrauterine adhesions (IUAs) in women underwent curettage in the second trimester.
methodsBetween June 2016 and September 2017, 60 patients who underwent curettage for retained placental tissue after medically induced or spontaneous pregnancy loss in the second trimester were enrolled in the study. The patients were randomly assigned to 1 of 2 groups: Group 1 patients received curettage plus NCH gel (intervention group), and group 2 patients received curettage alone (control group). The main outcomes were the rate and severity of IUA formation, which were assessed by follow-up hysteroscopy performed in the ensuing 2-6 months.
resultsThe hysteroscopic findings were available for 20 patients in group 1 and 28 patients in group 2. IUAs were observed in 6 patients in group 2, while no IUAs was observed in group 1 (
conclusionsOur study demonstrates that NCH gel appears to be able to reduce the formation of IUAs in women who undergo curettage in the second trimester, although larger controlled, randomized, multicenter studies are needed to confirm these results.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.