Evidence map›Paper›PMID 30524168›Full record

ArticleMedical archives (Sarajevo, Bosnia and Herzegovina)2018

Neurocognitive Endophenotypes of Schizophrenia and Bipolar Disorder and Possible Associations with FKBP Variant rs3800373.

Amra Memic, Fabian Streit, Lejla Hasandedic, Stephanie H Witt, Jana Strohmaier, Marcella Rietschel, Lilijana Oruc

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In one paragraph

Article in Medical archives (Sarajevo, Bosnia and Herzegovina), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Attention/Working Memory and Executive Function in Parkinson's Disease: Review, Critique, and Recommendations.Movement disorders : official journal of the Movement Disorder Society · 2025
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4 · The record

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5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Amra MemicPsychiatric Clinic, Clinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
Fabian StreitDepartment of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.
Lejla HasandedicPsychology Department, Faculty of Letters, Akdeniz University, Antalya, Turkey.
Stephanie H WittDepartment of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.
Jana StrohmaierDepartment of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.
Marcella RietschelDepartment of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.
Lilijana OrucPsychiatric Clinic, Clinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
University Hospital Heidelberg · DEUniversity of Sarajevo · BAAkdeniz University · TRCentral Institute of Mental Health · DEHeidelberg University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSchizophrenia(SCZ) and Bipolar disorder (BD) are frequently occurring and impairing disorders that affect around 1% of the population. Important endophenotypes in the genetic research of SCZ and BD are cognitive functions. Core symptoms for SCZ and BD are impairments in working memory, declarative memory and attention, all of which fulfill the criteria for an endophenotype. The FK506 Binding Protein 5 (FKBP5) gene codes for a co-chaperone of the glucocorticoid receptor and has been reported to be associated with cognition.

aimThe aims of our research were to determine the degree of cognitive impairment in patients suffering from SCZ and BD and to explore the association of the FKBP5 variant rs3800373 genotype with the cognitive endophenotypes. MATERIAL AND

methodsPatients and healthy controls were recruited over a period of two years from the Psychiatric Clinic, Clinical Center University of Sarajevo. Genotyping and neuropsychological assessments were performed for 263 subjects (129 SCZ, 53 BD, and 81 healthy controls [HC]). Neuropsychological assessments were performed for all patients with the Trail Making Test-A&B (TMT-A&B) and Digit-span forward&backwards tasks. The single nucleotide polymorphism (SNP) rs3800373 in the RESULTS AND

conclusionSCZ and BD patients performed lower than HC in the TMT-A&B and in the Digit-span backwards task, while no differences were observed between SCZ and BD patients. While SCZ patients performed lower than HC in the Digit-span forwards task, there were no differences between BD and HC or between BD and SCZ. Rs 3800373 was not associated with performance in the TMT-A&B or Digit-span forwards&backwards tasks. SCZ and BD share largely overlapping neurocognitive characteristics. Rs3800373 was not associated with performance in the neuropsychological tests. However, given the limited sample size, the results do not exclude an association with the rs3800373 variant in a larger sample. Furthermore, as the analysis was limited to one SNP, the results cannot be generalized to other genetic variants in

Indexed as

AdultBipolar DisorderCase-Control StudiesCognition DisordersEndophenotypesFemaleGenetic VariationHumansMaleNeuropsychological TestsProspective StudiesSchizophreniaTacrolimus Binding ProteinsTacrolimus Binding Proteinsbipolar disorderendophenotypesSchizophreniatacrolimus binding protein 5

Identifiers

PMID30524168
PMCPMC6282916
OpenAlexW2896127102

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.