Evidence map›Paper›PMID 30524163›Full record

ArticleMedical archives (Sarajevo, Bosnia and Herzegovina)2018

Hepatitis C Treatment in Patients with Drug Addiction Is Effective or Not Effective?

Seyed Amineh Hojati, Elham Maserat, Mohammad Ghorbani, Alireza Safarpour, Mohammad Reza Fattehi

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PubMed Full text at PMC Publisher
In one paragraph

Article in Medical archives (Sarajevo, Bosnia and Herzegovina), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 80% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Seyed Amineh HojatiGastrointestinal and Liver Diseases Research Center (GLDRC), Razi Hospital, Guilan University of Medical Sciences (GUMS), Rasht, Iran.
Elham MaseratHealth Information Technology Department, School of. Management and Medical informatics, Tabriz University of Medical Sciences, Tabriz, Iran.
Mohammad GhorbaniCollaboration Center of Meta-Analysis Research, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.
Alireza SafarpourGastroenterohepatology Research Center, Shiraz University of Medical of Sciences, Shiraz, Iran.
Mohammad Reza FattehiGastroenterohepatology Research Center, Shiraz University of Medical of Sciences, Shiraz, Iran.
Shiraz University of Medical Sciences · IRHealth Information Management · BERazi Hospital · IRTorbat Heydarieh University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPatients with drug addiction have high risk for hepatitis C virus (HCV). Effective treatment response is essential to optimize treatment for drug abusers infected by hepatitis C virus.

aimThe aim of this present study was to show that hepatitis C treatment in patients with drug addiction is effective like patients without drug addiction. MATERIAL AND

methodsTotal amount of 57 patients with hepatitis C (25 drug abuser and 32 non-drug abuser) that referred to Shahid Motahari clinic of Shiraz were selected. All patients infected with HCV treated by combination regimens of ribavirin, sofosbuvir and interferon. Patients received sofosbuvir (400mg once a day) in combination with peg-IFN-alpha (92a180m/w›92b1/5m/kg/w) and RBV (under 75 kg 1000mg, over 75 kg 12000kg) for 12 weeks. The Kolmogorov-Smirnov test was used for testing normality. Associations between variables were analyzed using a Chi-square, Fisher exact, T student and Mann-Whitney U test.

resultsOut of 25 HCV patients (43.9%) were drug addicts and 32 patients (56.1%) were non-drug addicts. Insomnia (61.4%), fatigue (63.1%) and debility (49.1%) were more common adverse effects of therapy in drug abusers and non-drug abusers. Alanine transaminase (ALT) and HCV RNA was normal in the end of therapy (EOT). White blood cell (WBC) count decreased in during two-week after starting of the treatment and then increased to normal levels at the end of treatment. Reduction of WBC count was considerable in during two-week. Hematologic result was not considerable. Reduction of hemoglobin was <10 g/dL in 9.37% of non-injecting drug addicts and <8.5 g/dL in 6.25% of injecting drug addicts. The results of this study did not demonstrated a significant relationship about sustained virologic response (SVR) between the drug abusers and non-drug abusers (P = 0.99).

conclusionsIn conclusion, patients with drug addiction can receive hepatitis C treatment on the history of their past or current drug use status. Combination therapy with sofosbuvir plus peginterferon and ribavirin can lead to high treatment response in HCV patients were drug abuser. In addition, this treatment combination was with low discontinuation rates and low adverse effects. Effective intervention in HCV patients with drug addiction to reduce injection- related risk.

Indexed as

Drug UsersAdultAntiviral AgentsDrug Therapy, CombinationFemaleHepacivirusHepatitis C, ChronicHumansInterferon-alphaMaleMiddle AgedRibavirinSofosbuvirTreatment OutcomeViral LoadAntiviral AgentsInterferon-alphaRibavirinSofosbuvirDrug AddictionHepatitis C virusTreatment

Identifiers

PMID30524163
PMCPMC6282910
OpenAlexW2897703505

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.