ArticleCirculation2018
Association Between Ambient Air Pollution and Cardiac Morpho-Functional Phenotypes: Insights From the UK Biobank Population Imaging Study.
Article in Circulation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 107 citations in OpenAlex.
- Pooled it
- Association between particulate matter air pollution and subclinical myocardial fibrosis in structurally normal hearts: a CMR-based study.European heart journal. Cardiovascular Imaging · 2026Article
- Air Pollution and Cardiac Remodeling and Function in Patients With Breast Cancer.JAMA network open · 2026Article
- The C-reactive protein-triglyceride glucose index (CTI) predicts mortality in cardiovascular-kidney-metabolic syndrome: a dual-cohort study with machine learning validation.International journal of surgery (London, England) · 2026Article
- The joint effects of multiple air pollutants, genetic susceptibility, and their interactions on incident cardiovascular disease, arrhythmia, and mortality.Scientific reports · 2025Article
- Ambient Air Pollution Exposure and Mortality in the Pulmonary Hypertension Association Registry.Annals of the American Thoracic Society · 2025Article
- Left ventricular concentric remodeling is highly common among veterans deployed to Southwest Asia and is associated with impaired exercise performance.Physiological reports · 2025Article
- Association between Long-term Exposure to Ambient Air Pollution and Myocardial Fibrosis Assessed with Cardiac MRI.Radiology · 2025Article
- Joint association of air pollutants on cardiometabolic multimorbidity.Scientific reports · 2024Article
- Association between Long-Term Exposure to Traffic-Related Air Pollution and Cardio-Metabolic Phenotypes: An MRI Data-Based Analysis.Environmental science & technology · 2024Article
- Heterogeneous associations of multiplexed environmental factors and multidimensional aging metrics.Nature communications · 2024Article
- Toward Heart-Healthy and Sustainable Cities: A Policy Statement From the American Heart Association.Circulation · 2024Review
- Pulmonary vascular disease, environmental pollution, and climate change.Pulmonary circulation · 2024Review
- Global Air Pollutant Phenanthrene and Arrhythmic Outcomes in a Mouse Model.Environmental health perspectives · 2023Article
- Air pollution is associated with abnormal left ventricular diastolic function: a nationwide population-based study.BMC public health · 2023Article
- Artificial intelligence can detect left ventricular dilatation on contrast-enhanced thoracic computer tomography relative to cardiac magnetic resonance imaging.The British journal of radiology · 2022Article
- Ambient air pollution, healthy diet and vegetable intakes, and mortality: a prospective UK Biobank study.International journal of epidemiology · 2022Article
- Exposure to Elevated Nitrogen Dioxide Concentrations and Cardiac Remodeling in Patients With Dilated Cardiomyopathy.Journal of cardiac failure · 2022Observational
- Impacts of Environmental Insults on Cardiovascular Aging.Current environmental health reports · 2022Review
- The Association of Ambient Air Pollution With Cataract Surgery in UK Biobank Participants: Prospective Cohort Study.Investigative ophthalmology & visual science · 2021Article
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Authors and funding
16 authors at 5 institutions in 2 countries.
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Abstract
Background: Exposure to ambient air pollution is strongly associated with increased cardiovascular morbidity and mortality. Little is known about the influence of air pollutants on cardiac structure and function. We aim to investigate the relationship between chronic past exposure to traffic-related pollutants and the cardiac chamber volume, ejection fraction, and left ventricular remodeling patterns after accounting for potential confounders. Methods: Exposure to ambient air pollutants including particulate matter and nitrogen dioxide was estimated from the Land Use Regression models for the years between 2005 and 2010. Cardiac parameters were measured from cardiovascular magnetic resonance imaging studies of 3920 individuals free from pre-existing cardiovascular disease in the UK Biobank population study. The median (interquartile range) duration between the year of exposure estimate and the imaging visit was 5.2 (0.6) years. We fitted multivariable linear regression models to investigate the relationship between cardiac parameters and traffic-related pollutants after adjusting for various confounders. Results: The studied cohort was 62±7 years old, and 46% were men. In fully adjusted models, particulate matter with an aerodynamic diameter <2.5 μm concentration was significantly associated with larger left ventricular end-diastolic volume and end-systolic volume (effect size = 0.82%, 95% CI, 0.09-1.55%, Conclusions: In a large asymptomatic population with no prevalent cardiovascular disease, higher past exposure to particulate matter with an aerodynamic diameter <2.5 μm and nitrogen dioxide was associated with cardiac ventricular dilatation, a marker of adverse remodeling that often precedes heart failure development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.