Evidence map›Paper›PMID 30524090›Full record

ReviewPhysics in medicine and biology2019

Radioluminescence in biomedicine: physics, applications, and models.

Justin S Klein, Conroy Sun, Guillem Pratx

Abstract readReview
In one paragraph

Review in Physics in medicine and biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 73 citations in OpenAlex.

  1. Let There be Light! Light as an Engine and Regulator in Synthetic Cells.Angewandte Chemie (International ed. in English) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Justin S KleinDepartment of Radiation Oncology, Stanford University, Stanford, CA 94305, United States of America.ORCID 0000-0002-1543-3082
Conroy SunCollege of Pharmacy, Oregon State University, Portland, OR 97201, United States of America.ORCID 0000-0001-5193-6907
Guillem PratxDepartment of Radiation Oncology, Stanford University, Stanford, CA 94305, United States of America.ORCID 0000-0002-0247-6470
Stanford University · USOregon State University · US

Funding

Stanford Molecular Imaging Scholars (SMIS) ProgramT32CA118681 · NCI · STANFORD UNIVERSITY · PI CRAIG S LEVIN · 2016 to 2026
$4.3M
Synergistic combination of nanotechnology and radiation in medicineR35GM119839 · NIGMS · OREGON STATE UNIVERSITY · PI SUN, CONROY GHIN CHEE · 2016 to 2020
$1.8M
Quantitative Imaging of Cancer Drug Resistance via Radioluminescence MicroarraysR01CA186275 · NCI · STANFORD UNIVERSITY · PI PRATX, GUILLEM · 2014 to 2018
$1.7M
High-throughput radionuclide counting and sorting of single cellsR21CA193001 · NCI · STANFORD UNIVERSITY · PI PRATX, GUILLEM · 2015 to 2017
$698k
NCI NIH HHS R01 CA186275NCI NIH HHS R21 CA193001NCI NIH HHS T32 CA118681NIGMS NIH HHS R35 GM119839
6 · The paper itself

Abstract

The electromagnetic spectrum contains different frequency bands useful for medical imaging and therapy. Short wavelengths (ionizing radiation) are commonly used for radiological and radionuclide imaging and for cancer radiation therapy. Intermediate wavelengths (optical radiation) are useful for more localized imaging and for photodynamic therapy (PDT). Finally, longer wavelengths are the basis for magnetic resonance imaging and for hyperthermia treatments. Recently, there has been a surge of interest for new biomedical methods that synergize optical and ionizing radiation by exploiting the ability of ionizing radiation to stimulate optical emissions. These physical phenomena, together known as radioluminescence, are being used for applications as diverse as radionuclide imaging, radiation therapy monitoring, phototherapy, and nanoparticle-based molecular imaging. This review provides a comprehensive treatment of the physics of radioluminescence and includes simple analytical models to estimate the luminescence yield of scintillators and nanoscintillators, Cherenkov radiation, air fluorescence, and biologically endogenous radioluminescence. Examples of methods that use radioluminescence for diagnostic or therapeutic applications are reviewed and analyzed in light of these quantitative physical models of radioluminescence.

Indexed as

Electromagnetic RadiationLuminescenceModels, TheoreticalHumansMolecular ImagingPhotochemotherapyPhysics

Identifiers

PMID30524090
PMCPMC6551203
OpenAlexW2902615480

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.