ArticleJournal of neural engineering2019
Epiretinal stimulation with local returns enhances selectivity at cellular resolution.
Article in Journal of neural engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 51 citations in OpenAlex.
- Restorative and regenerative therapies for vision loss.Eye (London, England) · 2026Review
- Leveraging current steering and the biophysics of spike generation for cellular-resolution electrical stimulation of neurons.Cell reports · 2026Article
- A three-dimensional bipolar microneedle electrode array with local ground integrated at each sidewall for enhanced focal electric stimulation.Microsystems & nanoengineering · 2025Article
- Optimizing electrical stimulation parameters to enhance visual cortex activation in retina degeneration rats.Scientific reports · 2025Article
- Article
- Focal stimulation of retinal ganglion cells using subretinal 3D microelectrodes with peripheral electrodes of opposite current.Biomedical engineering letters · 2024Article
- Inferring light responses of primate retinal ganglion cells using intrinsic electrical signatures.Journal of neural engineering · 2023Article
- High-Fidelity Reproduction of Visual Signals by Electrical Stimulation in the Central Primate Retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Retinal Prostheses: Engineering and Clinical Perspectives for Vision Restoration.Sensors (Basel, Switzerland) · 2023Review
- From retina to motoneurons: A substrate for visuomotor transformation in salamanders.The Journal of comparative neurology · 2022Article
- Differences in the spatial fidelity of evoked and spontaneous signals in the degenerating retina.Frontiers in cellular neuroscience · 2022Article
- In vivo chromatic and spatial tuning of foveolar retinal ganglion cells in Macaca fascicularis.PloS one · 2022Article
- Spatially patterned bi-electrode epiretinal stimulation for axon avoidance at cellular resolution.Journal of neural engineering · 2021Article
- Neuromodulation using electroosmosis.Journal of neural engineering · 2021Article
- Automatic Identification of Axon Bundle Activation for Epiretinal Prosthesis.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2021Article
- Targeted Stimulation of Retinal Ganglion Cells in Epiretinal Prostheses: A Multiscale Computational Study.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2020Article
- Computational challenges and opportunities for a bi-directional artificial retina.Journal of neural engineering · 2020Article
- Probing and predicting ganglion cell responses to smooth electrical stimulation in healthy and blind mouse retina.Scientific reports · 2020Article
- Stimulation Strategies for Improving the Resolution of Retinal Prostheses.Frontiers in neuroscience · 2020Review
- Single-Cell Electrical Stimulation Using CMOS-Based High-Density Microelectrode Arrays.Frontiers in neuroscience · 2019Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveEpiretinal prostheses are designed to restore vision in people blinded by photoreceptor degenerative diseases, by directly activating retinal ganglion cells (RGCs) using an electrode array implanted on the retina. In present-day clinical devices, current spread from the stimulating electrode to a distant return electrode often results in the activation of many cells, potentially limiting the quality of artificial vision. In the laboratory, epiretinal activation of RGCs with cellular resolution has been demonstrated with small electrodes, but distant returns may still cause undesirable current spread. Here, the ability of local return stimulation to improve the selective activation of RGCs at cellular resolution was evaluated. APPROACH: A custom multi-electrode array (512 electrodes, 10 μm diameter, 60 μm pitch) was used to simultaneously stimulate and record from RGCs in isolated primate retina. Stimulation near the RGC soma with a single electrode and a distant return was compared to stimulation in which the return was provided by six neighboring electrodes. MAIN
resultsLocal return stimulation enhanced the capability to activate cells near the central electrode (<30 μm) while avoiding cells farther away (>30 μm). This resulted in an improved ability to selectively activate ON and OFF cells, including cells encoding immediately adjacent regions in the visual field. SIGNIFICANCE: These results suggest that a device that restricts the electric field through local returns could optimize activation of neurons at cellular resolution, improving the quality of artificial vision.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.