ArticleJournal of neural engineering2019
Chronic intracochlear electrical stimulation at high charge densities results in platinum dissolution but not neural loss or functional changes in vivo.
Article in Journal of neural engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Sodium hexachloroplatinate (IV) induces concentration- and time-dependent depolarization and cytotoxicity in HEI-OC1 auditory cells.PloS one · 2026Article
- Overcoming failure: improving acceptance and success of implanted neural interfaces.Bioelectronic medicine · 2025Review
- A Novel Trans-Impedance Matrix (TIM) Abnormality Pattern in Cochlear Implants.Audiology research · 2025Article
- Failure behavior of polymer microelectrode arrays encapsulated with conventional ALD and 3D-ALI barriers.Frontiers in bioengineering and biotechnology · 2025Article
- Bioelectronic Neural Interfaces: Improving Neuromodulation Through Organic Conductive Coatings.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- NeurostimML: a machine learning model for predicting neurostimulation-induced tissue damage.Journal of neural engineering · 2024Article
- Article
- Chronic electrical stimulation with a peripheral suprachoroidal retinal implant: a preclinical safety study of neuroprotective stimulation.Frontiers in cell and developmental biology · 2024Article
- Quantification of safe operation conditions for large-area platinum-iridium electrodes in neurostimulation application.PloS one · 2024Article
- A Comparative Study on the Effect of Substrate Structure on Electrochemical Performance and Stability of Electrodeposited Platinum and Iridium Oxide Coatings for Neural Electrodes.Micromachines · 2023Article
- PEDOT:PSS-coated platinum electrodes for neural stimulation.APL bioengineering · 2023Article
- Electrical stimulation of cochlear implant promotes activation of macrophages and fibroblasts under inflammation.Laryngoscope investigative otolaryngology · 2023Article
- Article
- Electrical epidural stimulation of the cervical spinal cord: implications for spinal respiratory neuroplasticity after spinal cord injury.Journal of neurophysiology · 2021Review
- Viral-mediated transduction of auditory neurons with opsins for optical and hybrid activation.Scientific reports · 2021Article
- Platinum dissolution and tissue response following long-term electrical stimulation at high charge densities.Journal of neural engineering · 2021Article
- Tutorial: guidelines for standardized performance tests for electrodes intended for neural interfaces and bioelectronics.Nature protocols · 2020Review
- Chronic intracochlear electrical stimulation at high charge densities: reducing platinum dissolution.Journal of neural engineering · 2020Article
- Stem Cell Based Drug Delivery for Protection of Auditory Neurons in a Guinea Pig Model of Cochlear Implantation.Frontiers in cellular neuroscience · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveAlthough there are useful guidelines defining the boundary between damaging and non-damaging electrical stimulation they were derived from acute studies using large surface area electrodes in direct contact with cortical neurons. These parameters are a small subset of the parameters used by neural stimulators. More recently, histological examination of cochleae from patients that were long-term cochlear implant users have shown evidence of particulate platinum (Pt). The pathophysiological effect of Pt within the cochlea is unknown. We examined the response of the cochlea to stimulus levels beyond those regarded as safe, and to evaluate the pathophysiological response of the cochlea following chronic stimulation at charge densities designed to induce Pt corrosion in vivo. APPROACH: 19 guinea pigs were systemically deafened and implanted with a cochlear electrode array containing eight Pt electrodes of 0.05, 0.075 or 0.2 mm MAIN
resultsCompared with unstimulated control electrodes and electrodes stimulated at 100 µC/cm SIGNIFICANCE: Chronic electrical stimulation of Pt electrodes at 267 or 400 µC/cm
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.