Evidence map›Paper›PMID 30523755›Full record

ArticleCell cycle (Georgetown, Tex.)2018

TGF-β secreted by tumor-associated macrophages promotes proliferation and invasion of colorectal cancer via miR-34a-VEGF axis.

Danhua Zhang, Xinguang Qiu, Jianhua Li, Shouhua Zheng, Liwen Li, Hongchao Zhao

RetractedOpen access · bronzeAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 51 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 2 pooled it
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Danhua Zhanga Department of General surgery , The First Affiliated Hospital of Zhengzhou University , Zhengzhou , Henan Province , China.
Xinguang Qiua Department of General surgery , The First Affiliated Hospital of Zhengzhou University , Zhengzhou , Henan Province , China.
Jianhua Lia Department of General surgery , The First Affiliated Hospital of Zhengzhou University , Zhengzhou , Henan Province , China.
Shouhua Zhenga Department of General surgery , The First Affiliated Hospital of Zhengzhou University , Zhengzhou , Henan Province , China.
Liwen Lia Department of General surgery , The First Affiliated Hospital of Zhengzhou University , Zhengzhou , Henan Province , China.
Hongchao Zhaoa Department of General surgery , The First Affiliated Hospital of Zhengzhou University , Zhengzhou , Henan Province , China.
First Affiliated Hospital of Zhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor-associated macrophages (TAMs) were reported to be involved in colorectal cancer (CRC) progression. However, its biological role and underlying mechanism in CRC remained to be elucidated. In this study, the expressions of the macrophage marker CD68 and transforming growth factor β1 (TGF-β1) in CRC tumor tissues and adjacent tissues were detected by immunohistochemistry. The expression levels of miR-34a, TGF-β1 and vascular endothelial growth factor (VEGF) in CRC tumor tissues and peripheral blood macrophages were measured by quantitative real-time PCR (qRT-PCR) and western blot. TGF-β1 levels in culture supernatant were detected by ELISA. The cell proliferation and invasion of human CRC cell lines CL187 and HCT116 were determined by MTT assay and Transwell assay, respectively. The results showed that the expression of miR-34a was downregulated whereas TGF-β1 and VEGF were upregulated in CRC tumor tissues and peripheral blood macrophages. TGF-β1 secreted by TAMs promoted the proliferation and invasion of CRC cells. TGF-β1-mediated miR-34a downregulation contributed to the proliferation and invasion of CRC cells via upregulating VEGF. MiR-34a in vivo exerted anti-tumor effect in CRC via inhibiting VEGF expression. In conclusion, TGF-β1 secreted by TAMs promoted CRC proliferation and invasion through regulating miR-34a/VEGF axis.

Indexed as

Cell ProliferationAnimalsAntagomirsCell Line, TumorCell MovementColorectal NeoplasmsFemaleGene Expression Regulation, NeoplasticHumansMacrophagesMaleMiceMice, NudeMicroRNAsMiddle AgedNeoplasm MetastasisAntagomirsMicroRNAsMIRN34 microRNA, humanRNA, Small InterferingTransforming Growth Factor betaVascular Endothelial Growth Factor AColorectal cancerinvasionproliferationTGF-β1tumor-associated macrophages

Identifiers

PMID30523755
PMCPMC6343734
OpenAlexW2905375533

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.