ReviewJournal of nephrology2019
When kidneys and lungs suffer together.
Review in Journal of nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 36 citations in OpenAlex.
- Demographic and regional disparities in concurrent respiratory and renal failure mortality: a CDC WONDER analysis, 1999-2024.Scientific reports · 2026Article
- Impact of CKD and COPD co-existence on mortality, vascular dementia, and Alzheimer's dementia; a comparative cohort study.BMC nephrology · 2026Observational
- Review
- The Association Between Stomach Disease and Chronic Obstructive Pulmonary Disease: A Cross-Sectional Analysis of the 2018 China Health and Retirement Longitudinal Study (CHARLS).International journal of chronic obstructive pulmonary disease · 2026Article
- Genetic analysis of elevated levels of creatinine and cystatin C biomarkers reveals novel genetic loci associated with kidney function.Human molecular genetics · 2025Article
- Association and risk of blood urea nitrogen-to-creatinine ratio with congestive heart failure in critically ill COPD patients.BMC pulmonary medicine · 2025Article
- Impact of nutritional status and pulmonary function on short- and long-term overall survival in hemodialysis patients.PloS one · 2025Article
- Efficacy and safety of extracorporeal membrane oxygenation combined with continuous renal replacement therapy in the management of pediatric acute respiratory distress syndrome.Frontiers in pediatrics · 2025Article
- Development and validation of a Multi-Causal investigation and discovery framework for knowledge harmonization (MINDMerge): A case study with acute kidney injury risk factor discovery using electronic medical records.International journal of medical informatics · 2024Article
- Association between renal dysfunction and outcomes of lung cancer: A systematic review and meta‑analysis.Oncology letters · 2024Article
- Association between serum creatinine and 30 days all-cause mortality in critically ill patients with non-traumatic subarachnoid hemorrhage: analysis of the MIMIC-IV database.Frontiers in neurology · 2024Article
- The Relationship Between Blood Urea Nitrogen to Creatinine Ratio and Severe Acute Exacerbation of COPD Patients: A Propensity Score Matching Study.International journal of chronic obstructive pulmonary disease · 2024Article
- Development and validation of a nomogram to predict the risk of vancomycin-related acute kidney injury in critical care patients.Frontiers in pharmacology · 2024Article
- Nontraditional Risk Factors for Progression Through Chronic Kidney Disease Risk Categories: The Coronary Artery Risk Development in Young Adults Study.The American journal of medicine · 2023Article
- Comorbid conditions as predictors of mortality in severe COPD - an eight-year follow-up cohort study.European clinical respiratory journal · 2023Article
- Racial Differences and Contributory Cardiovascular and Non-Cardiovascular Risk Factors Towards Chronic Kidney Disease Progression.Vascular health and risk management · 2023Article
- Development of a new prognostic index PNPI for prognosis prediction of CKD patients with pneumonia at hospital admission.Frontiers in medicine · 2023Article
- Change for the Better: Severe Pneumonia at the Emergency Department.Pathogens (Basel, Switzerland) · 2022Article
- Is There an Association Between Chronic Obstructive Pulmonary Disease and Chronic Renal Failure?Cureus · 2022Review
- Prolonged Mechanical Ventilation: Outcomes and Management.Journal of clinical medicine · 2022Review
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A significant interaction between kidneys and lungs has been shown in physiological and pathological conditions. The two organs can both be targets of the same systemic disease (eg., some vasculitides). Moreover, loss of normal function of either of them can induce direct and indirect dysregulation of the other one. Subjects suffering from COPD may have systemic inflammation, hypoxemia, endothelial dysfunction, increased sympathetic activation and increased aortic stiffness. As well as the exposure to nicotine, all the foresaid factors can induce a microvascular damage, albuminuria, and a worsening of renal function. Renal failure in COPD can be unrecognized since elderly and frail patients may have normal serum creatinine concentration. Lungs and kidneys participate in maintaining the acid-base balance. Compensatory role of the lungs rapidly expresses through an increase or reduction of ventilation. Renal compensation usually requires a few days as it is achieved through changes in bicarbonate reabsorption. Chronic kidney disease and end-stage renal diseases increase the risk of pneumonia. Vaccination against Streptococcus pneumonia and seasonal influenza is recommended for these patients. Vaccines against the last very virulent H1N1 influenza A strain are also available and effective. Acute lung injury and acute kidney injury are frequent complications in critical illnesses, associated with high morbidity and mortality. The concomitant failure of kidneys and lungs implies a multidisciplinary approach, both in terms of diagnostic processes and therapeutic management.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.