Evidence map›Paper›PMID 30523551›Full record

ArticleJournal of natural medicines2019

Gastroprotective effect of araloside A on ethanol- and aspirin-induced gastric ulcer in mice: involvement of H

Haibo He, Xiaomei Li, Haili Yu, Shu Zhu, Yumin He, Katsuko Komatsu, Dongyan Guo, Xiaoqin Li, Junzhi Wang, Huajun Luo and 2 more

Abstract read
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In one paragraph

Article in Journal of natural medicines, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 59 citations in OpenAlex.

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  12. Gastroprotective effects ofSaudi journal of biological sciences · 2023
    Article
  13. C-Phycocyanin andNutrients · 2022
    Article
  14. Pharmacological Basis ofMolecules (Basel, Switzerland) · 2022
    Article
  15. Article
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  17. Effect ofFrontiers in pharmacology · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Haibo HeHubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, 8 University Avenue, Yichang, 443002, China.
Xiaomei LiHubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, 8 University Avenue, Yichang, 443002, China.
Haili YuHubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, 8 University Avenue, Yichang, 443002, China.
Shu ZhuDivision of Pharmacognosy, Department of Medicinal Resources, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.
Yumin HeHubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, 8 University Avenue, Yichang, 443002, China.
Katsuko KomatsuDivision of Pharmacognosy, Department of Medicinal Resources, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.
Dongyan GuoShaanxi Key Laboratory of Traditional Chinese Medicine Foundation and New Drug Research, Shaanxi University of Chinese Medicine, Shiji Road, Xianyang, 712046, China. dyguo@126.com.
Xiaoqin LiHubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, 8 University Avenue, Yichang, 443002, China.
Junzhi WangHubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, 8 University Avenue, Yichang, 443002, China. horsedog@163.com.
Huajun LuoHubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, 8 University Avenue, Yichang, 443002, China.
Daoxiang XuSeventh People's Hospital of Wenzhou, 552 Shanxi East Road, Wenzhou, 325005, China.
Kun ZouHubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, 8 University Avenue, Yichang, 443002, China.
China Three Gorges University · CNUniversity of Toyama · JPShaanxi University of Chinese Medicine · CNWenzhou City People's Hospital · CN

Funding

National Natural Science Foundation of China 31370373National Natural Science Foundation of China 81202905
6 · The paper itself

Abstract

The aim of this study was to elucidate the gastroprotective activity and possible mechanism of involvement of araloside A (ARA) against ethanol- and aspirin-induced gastric ulcer in mice. The experimental mice were randomly divided into control, model, omeprazole (20 mg/kg, orally) and ARA (10, 20 and 40 mg/kg, orally). Gastric ulcer in mice was induced by intragastric administration of 80% ethanol (10 mL/kg) containing 15 mg/mL aspirin 4 h after drug administration on day 7. The results indicated that ARA could significantly raise gastric juice volume and acidity; ameliorate gastric mucosal blood flow, gastric binding mucus volume, ulcer index and ulcer inhibition rate; suppress H

Indexed as

AnimalsAnti-Ulcer AgentsApoptotic Protease-Activating Factor 1AraliaAspirinCaspase 3Caspase 9Cytochromes cDrug Evaluation, PreclinicalEthanolGastric JuiceGastric MucosaH(+)-K(+)-Exchanging ATPaseMaleMiceMitochondriaAnti-Ulcer AgentsApaf1 protein, mouseApoptotic Protease-Activating Factor 1araloside AAspirinCasp3 protein, mouseCasp9 protein, mouseCaspase 3Caspase 9Cytochromes cEthanolH(+)-K(+)-Exchanging ATPaseOleanolic AcidParp1 protein, mousePlant ExtractsPoly (ADP-Ribose) Polymerase-1Proto-Oncogene Proteins c-bcl-2SaponinsApoptosisAraloside AGastric ulcerH+/K+-ATPaseMitochondrial-mediated signaling pathway

Identifiers

PMID30523551
OpenAlexW2903936149

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.